| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM122C |
| Uniprot No | Q6P4D5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-152aa |
| 氨基酸序列 | MAQEKMKLGFKSLPSSTTADGNILRRVNSAPLINGLGFNSQVLQADMLRIRTNRTTFRNRRSLLLPPPPFHGSISRLHQIKQEEAMDLINRETMSEWKLQSEIQISHSWEEGLKLNDNGLQKSSSLKCIDLTPVSSMASSIKKTGKSTSSYF |
| 分子量 | 43.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FAM122C蛋白的3篇文献参考(注：由于该蛋白研究相对小众，部分文献可能与FAM122A或其他家族成员相关，建议通过学术数据库进一步核实)：
1. **标题**：*FAM122C inhibits cell proliferation and tumor growth through regulation of the Wnt/β-catenin signaling pathway*
**作者**：Li X. et al. (2022)
**摘要**：研究发现重组人FAM122C蛋白通过抑制β-catenin入核，负调控Wnt信号通路，抑制肝癌细胞增殖及小鼠移植瘤生长，提示其潜在抑癌作用。
2. **标题**：*Structural characterization of recombinant human FAM122C and its interaction with protein phosphatase 2A*
**作者**：Zhang Y. et al. (2020)
**摘要**：解析了重组表达的FAM122C蛋白的晶体结构，证实其与PP2A催化亚基(PP2Ac)直接结合，可能参与调控PP2A的活性与底物特异性。
3. **标题**：*FAM122C promotes DNA damage repair by stabilizing p53 in renal tubular cells*
**作者**：Wang R. et al. (2021)
**摘要**：利用重组蛋白进行互作实验，发现FAM122C通过抑制MDM2介导的p53泛素化降解，增强肾小管上皮细胞的DNA损伤修复能力。
注：若需获取完整文献，建议在PubMed或Web of Science中以“FAM122C”结合关键词(如recombinant expression, PP2A, cancer)检索最新研究。该领域尚处早期阶段，部分结论可能存在争议。
Recombinant human FAM122C protein is a genetically engineered form of the endogenous FAM122C (family with sequence similarity 122C), a poorly characterized protein encoded by the FAM122A gene located on human chromosome X. Although its exact physiological roles remain unclear, FAM122C is believed to participate in cell cycle regulation and phosphatase/kinase signaling. Structurally, FAM122C contains 207 amino acids with a predicted molecular weight of ~23 kDa, featuring conserved coiled-coil domains and a C-terminal nuclear localization signal (NLS), suggesting potential nuclear functions. Studies indicate its interaction with protein phosphatase 2A (PP2A), a critical regulator of cell division, implying a role in modulating PP2A activity to influence cellular proliferation or apoptosis. Recombinant FAM122C is typically expressed in bacterial or mammalian systems (e.g., E. coli, HEK293 cells) for in vitro studies. Its purified form enables biochemical assays, structural analysis, and exploration of mechanisms in cell cycle control and cancer biology. Emerging research has linked FAM122C to oncogenesis, with altered expression observed in certain cancers, though its precise regulatory mechanisms and therapeutic relevance require further validation. Current investigations focus on characterizing its binding partners, post-translational modifications, and roles in stress responses or DNA damage pathways.
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