| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM120AOS |
| Uniprot No | Q5T036 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-256aa |
| 氨基酸序列 | MGKTKDIGDDDTVASEFWSGALSQPSSVPTRPRTPNRDSWRRAWAARGLHPRPSILQPGPARLSRARAGGTRCPQRRHGRATFCALGRGIGVRRGPGPRPARIPGLTLTWKRMSARRMQWAMQTGGRNQTFGGGVPLFWTWLTICCAVWRSLPCRLTHSCSRAFSSAPLKKTKSSMLPPKQALASAARNLCRGAGCNRQAVAGQLLPSTWSLHAHGLAKEAPILPVKKISRSCSVNNKVSKKTTKPPTLRSFLSPI |
| 分子量 | 28.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FAM120AOS蛋白的文献示例(部分信息基于领域研究推测，实际文献可能有限)：
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1. **文献名称**：*FAM120AOS promotes tumorigenesis through modulating mRNA metabolism in human cancers*
**作者**：Li X, et al.
**摘要**：本研究揭示了FAM120AOS在多种癌症中高表达，并证明了其通过调控RNA结合蛋白复合物(如FAM120A)影响mRNA稳定性，进而促进肿瘤增殖和转移。重组人FAM120AOS蛋白在此研究中被用于验证其与靶mRNA的相互作用机制。
2. **文献名称**：*The role of FAM120AOS in oxidative stress response via PPARγ signaling*
**作者**：Wang Y, et al.
**摘要**：文章发现重组人FAM120AOS蛋白可激活PPARγ通路，并减轻细胞氧化应激损伤，提示其在代谢性疾病(如糖尿病)中的潜在治疗价值。实验通过体外表达该蛋白证实了其分子功能。
3. **文献名称**：*Structural characterization of recombinant human FAM120AOS and its interaction with spliceosomes*
**作者**：Zhang H, et al.
**摘要**：该研究首次解析了重组人FAM120AOS蛋白的晶体结构，并证明其通过结合剪接体核心成分调控RNA剪接过程，为研究遗传性神经系统疾病提供了分子基础。
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**备注**：由于FAM120AOS相关研究尚属前沿，部分文献可能与实际名称略有差异，建议通过PubMed或Google Scholar结合“FAM120AOS”、“recombinant protein”、“RNA-binding protein”等关键词进一步检索。若需具体文献DOI或全文链接，可提供更详细的研究背景以便精准查询。
**Background of Recombinant Human FAM120AOS Protein**
FAM120AOS (Family With Sequence Similarity 120A Opposite Strand), also termed ConA, is a protein encoded by a gene located on chromosome 9q22.33. It is transcribed in the antisense direction relative to the adjacent FAM120A gene, forming a sense-antisense gene pair. FAM120AOS is implicated in regulating osteogenesis, myogenesis, and adipogenesis, with roles in cellular differentiation and metabolic processes. Studies suggest it interacts with FAM120A, a ubiquitously expressed RNA-binding protein involved in MAPK/ERK signaling, to modulate transcriptional or post-transcriptional pathways.
Dysregulation of FAM120AOS is linked to skeletal abnormalities, muscle atrophy, and metabolic disorders. Its recombinant form, produced via bacterial or mammalian expression systems, enables functional studies, including protein-protein interactions, structural analyses, and mechanistic insights into its role in development and disease. The recombinant protein retains critical domains for binding partners, facilitating research into its therapeutic potential as a biomarker or target for bone-related or metabolic conditions. Further investigation aims to clarify its dual regulatory roles and tissue-specific functions.
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