| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM79B |
| Uniprot No | Q6ZUI0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-275aa |
| 氨基酸序列 | MSTIGSFEGFQAVSLKQEGDDQPSETDHLSMEEEDPMPRQISRQSSVTESTLYPNPYHQPYISRKYFATRPGAIETAMEDLKGHVAETSGETIQGFWLLTKIDHWNNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNAHKNSTGSGRGKKLMVLTEPILIETYTGLMSFIGNRNKLGYSLARGSIGF |
| 分子量 | 57.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3-4篇关于人FAM79B蛋白的模拟参考文献示例(请注意，部分研究可能尚未发表或存在不同研究方向，实际引用需以真实文献为准)：
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1. **文献名称**: *"Cloning and characterization of human FAM79B as a novel regulatory protein in keratinocyte differentiation"*
**作者**: Li X, Wang Q, et al.
**摘要**: 研究首次报道了人源FAM79B蛋白的基因克隆与原核/真核表达特性，发现其在表皮角质形成细胞分化中可能通过Wnt/β-catenin通路调控细胞增殖，并与银屑病等皮肤疾病相关。
2. **文献名称**: *"FAM79B interacts with PLK1 to promote tumorigenesis in cutaneous squamous cell carcinoma"*
**作者**: Zhang Y, Liu H, et al.
**摘要**: 揭示了FAM79B与激酶PLK1的直接结合，并通过稳定PLK1蛋白水平促进皮肤鳞状细胞癌的增殖和转移。重组FAM79B蛋白实验证实其对PLK1活性的正向调控作用。
3. **文献名称**: *"Proteomic analysis identifies FAM79B as a biomarker for early-stage pancreatic cancer detection"*
**作者**: Chen R, Zhou L, et al.
**摘要**: 通过质谱分析发现FAM79B在胰腺癌患者血清中异常高表达，重组蛋白的功能抑制实验表明其可能通过调控细胞周期相关蛋白(如Cyclin D1)影响肿瘤进展。
4. **文献名称**: *"FAM79B deficiency impairs spermatogenesis by disrupting acrosome formation in mice"*
**作者**: Wang T, Tanaka Y, et al.
**摘要**: 利用FAM79B基因敲除小鼠模型，证实该蛋白在精子顶体形成中发挥关键作用，重组人FAM79B蛋白可部分挽救体外培养的缺陷型生殖细胞功能。
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**建议**：实际研究中，请通过 **PubMed**(https://pubmed.ncbi.nlm.nih.gov)或 **Google Scholar** 输入关键词“FAM79B”或“recombinant human FAM79B”获取最新文献。部分真实研究可能聚焦于其与疾病(如癌症、生殖障碍)或信号通路(如MAPK、Wnt)的关联。
**Background of Recombinant Human FAM79B Protein**
Recombinant human FAM79B (Family With Sequence Similarity 79 Member B) is a protein encoded by the *FAM79B* gene, located on chromosome 15q21.2. The protein is primarily expressed in epithelial and neuronal tissues, suggesting potential roles in cellular differentiation, signaling, or tissue homeostasis. Structurally, FAM79B contains conserved domains that may mediate protein-protein interactions, though its precise molecular mechanisms remain under investigation.
Current research links FAM79B to cancer and neurological disorders. In melanoma, *FAM79B* overexpression correlates with tumor progression and altered MAPK signaling. Conversely, reduced expression has been observed in certain brain-related conditions, hinting at neuroprotective functions. Its interaction with cellular kinases and phosphatases further implicates it in regulating signaling pathways.
The recombinant form of FAM79B is typically produced in *E. coli* or mammalian expression systems, enabling studies on its biochemical properties and functional roles. Researchers utilize it to generate antibodies, map binding partners, or explore its involvement in diseases. Despite progress, the protein's full physiological significance and therapeutic potential remain unclear, necessitating further exploration of its context-dependent roles in health and disease.
This recombinant tool is critical for advancing insights into FAM79B’s contributions to cellular processes and its applicability as a biomarker or drug target.
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