| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM80A |
| Uniprot No | Q8IXN7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-350aa |
| 氨基酸序列 | MDQIAVTIVGGHLGLQLNQKALTTFPDVVLVRVPTPSVQSDSDITVLRHLEKLGCRLVNRPQSILNCINKFWTFQELAGHGVPMPDTFSYGGHEDFSKMIDEAEPLGYPVVVKSTRGHRGKAVFLARDKHHLSDICHLIRHDVPYLFQKYVKESHGKDIRVVVVGGQVIGSMLRCSTDGRMQSNCSLGGVGVKCPLTEQGKQLAIQVSNILGMDFCGIDLLIMDDGSFVVCEANANVGFLAFDQACNLDVGGIIADYTMSLLPNRQTGKMAVLPGLSSPREKNEPDGCASAQGVAESVYTINSGSTSSESEPELGEIRDSSASTMGAPPSMLPEPGYNINNRIASELKLK |
| 分子量 | 64.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3-4条关于重组人FAM80A蛋白的模拟参考文献示例(注：因实际文献数据有限，内容为基于研究的合理假设，建议结合真实数据库检索)：
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1. **文献名称**: *Cloning and functional characterization of human FAM80A as a methyltransferase in protein arginine modification*
**作者**: Zhang L, et al.
**摘要**: 本研究成功克隆并表达了重组人FAM80A蛋白，发现其具有甲基转移酶活性，可催化精氨酸残基的甲基化修饰，可能参与表观遗传调控和RNA代谢过程。
2. **文献名称**: *FAM80A regulates pancreatic cancer progression via Wnt/β-catenin signaling pathway*
**作者**: Wang Y, et al.
**摘要**: 通过重组FAM80A蛋白的功能实验，发现其能抑制胰腺癌细胞增殖和迁移，机制可能与结合β-catenin并下调Wnt通路靶基因表达有关。
3. **文献名称**: *Structural analysis of FAM80A reveals a novel domain essential for protein-protein interaction*
**作者**: Chen X, et al.
**摘要**: 该研究解析了重组FAM80A的晶体结构，发现其C端存在一个独特的α-螺旋结构域，与组蛋白修饰复合体的相互作用相关，为靶向药物设计提供了结构基础。
4. **文献名称**: *Downregulation of FAM80A correlates with poor prognosis in colorectal cancer*
**作者**: Kim S, et al.
**摘要**: 利用重组蛋白抗体检测肿瘤组织样本，发现FAM80A在结直肠癌中表达显著降低，且低表达与患者生存率下降相关，提示其可能作为潜在的肿瘤抑制因子。
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**建议**：实际文献可通过PubMed、Google Scholar等平台搜索关键词 "recombinant human FAM80A" 或 "FAM80A protein function"，并结合近五年研究筛选。
Recombinant human FAM80A protein is a genetically engineered form of the FAM80A (Family with sequence similarity 80 member A) protein, which plays a role in epigenetic regulation and cellular processes. FAM80A, also known as C6orf64. belongs to a conserved protein family with poorly understood functions. Studies suggest it interacts with histone acetyltransferase complexes, influencing histone modification and transcriptional regulation. It is expressed in various tissues, including testis, liver, and brain, and may contribute to developmental processes, such as spermatogenesis.
The recombinant variant is typically produced in bacterial or mammalian expression systems to enable biochemical and functional studies. Its purification facilitates investigations into molecular mechanisms, including protein-protein interactions, enzymatic activity assays, or structural analyses. Recent research highlights FAM80A’s potential involvement in cancer progression and fertility disorders, though specific pathways remain under investigation. Recombinant FAM80A serves as a critical tool for unraveling its role in chromatin remodeling, gene expression, and disease associations. Further studies aim to clarify its therapeutic relevance and utility as a biomarker in conditions linked to epigenetic dysregulation.
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