| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | GTDC1 |
| Uniprot No | Q4AE62 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-373aa |
| 氨基酸序列 | MSILIIEAFYGGSHKQLVDLLQEELGDCVVYTLPAKKWHWRARTSALYFSQTIPISEHYRTLFASSVLNLTELAALRPDLGKLKKILYFHENQLIYPVKKCQERDFQYGYNQILSCLVADVVVFNSVFNMESFLTSMGKFMKLIPDHRPKDLESIIRPKCQVIYFPIRFPDVSRFMPKHKTTHLKKMLGLKGNGGAVLSMALPFQPEQRDSEDLLKNFNSECDTHCGLDTARQEYLGNSLRQESDLKKSTSSDNSSSHHGENKQNLTVDPCDILGGVDNQQRLLHIVWPHRWLEAVYCGCYPLCPKDLVYPEIFPAEYLYSTPEQLSKRLQNFCKRPDIIRKHLYKGEIAPFSWAALHGKFRSLLTTEPREDL |
| 分子量 | 69.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人GTDC1蛋白的参考文献示例(部分内容为模拟，实际文献需通过学术数据库核实)：
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1. **文献名称**: *Expression and Purification of Recombinant Human GTDC1 in E. coli*
**作者**: Zhang L, et al.
**摘要**: 报道了利用大肠杆菌系统高效表达重组人GTDC1蛋白的方法，通过His标签亲和层析纯化蛋白，并验证其正确折叠及生物活性，为后续功能研究提供材料基础。
2. **文献名称**: *Structural Insights into GTDC1: Implications for Glycosylation Regulation*
**作者**: Kumar S, Gupta R.
**摘要**: 采用X射线晶体学解析了重组人GTDC1的胞外域结构，发现其可能参与糖基化修饰，并通过体外实验证实其与特定糖基转移酶的相互作用。
3. **文献名称**: *Functional Role of GTDC1 in Cancer Cell Invasion*
**作者**: Chen Y, et al.
**摘要**: 研究重组人GTDC1蛋白在癌细胞迁移中的作用，发现其通过调控细胞外基质黏附通路促进侵袭，为癌症治疗提供潜在靶点。
4. **文献名称**: *GTDC1 Knockdown and Recombinant Protein Rescue Assays in Neuronal Development*
**作者**: Wang H, Li J.
**摘要**: 构建重组人GTDC1蛋白并应用于神经元分化模型，证明其在轴突导向中起关键作用，补充实验恢复了基因敲低后的表型缺陷。
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**注意**：以上文献为示例性描述，实际研究需通过**PubMed**、**Web of Science**或**Google Scholar**等平台检索。若该蛋白研究较少，可尝试扩展关键词(如全称、别名或相关通路)。建议结合近期文献和综述获取最新进展。
Human GTDC1 (Glycosyltransferase-Like Domain Containing 1) is a protein encoded by the *GTDC1* gene, located on chromosome 2p16.1. It contains a glycosyltransferase-like domain, though its enzymatic activity remains unconfirmed, suggesting potential non-catalytic roles in cellular processes. GTDC1 is implicated in protein-protein interactions, possibly influencing cell adhesion, signaling, or extracellular matrix organization. Studies associate it with neurological functions, cancer progression, and developmental disorders, though its precise biological mechanisms are poorly characterized.
Recombinant human GTDC1 protein is produced using expression systems (e.g., *E. coli*, mammalian cells) for functional studies. Purified GTDC1 enables research on its structure, post-translational modifications, and binding partners. Its overexpression in certain cancers and regulatory roles in pathways like Wnt or TGF-β highlights therapeutic potential. However, limited literature underscores the need for further exploration into its physiological relevance, interaction networks, and disease associations. Current applications focus on antibody development, biochemical assays, and elucidating its contribution to cellular homeostasis or pathology.
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