| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | HOM-TES-103 |
| Uniprot No | Q0D2I5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-559aa |
| 氨基酸序列 | MNPLFGPNLF LLQQEQQGLA GPLGDSLGGD HFAGGGDLPP APLSPAGPAA YSPPGPGPAP PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL LEKQLQQALE EGKQGRRGLG RRDQAVQTGF VSPIRPLGLQ LGARPAAVCS PSARVLGSPA RSPAGPLAPS AASLSSSSTS TSTTYSSSAR FMPGTIWSFS HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA LYNVLAKVKR ERDEYKRRWE EEYTVRIQLQ DRVNELQEEA QEADACQEEL ALKVEQLKAE LVVFKGLMSN NLSELDTKIQ EKAMKVDMDI CRRIDITAKL CDVAQQRNCE DMIQMFQVPS MGGRKRERKA AVEEDTSLSE SEGPRQPDGD EEESTALSIN EEMQRMLNQL REYDFEDDCD SLTWEETEET LLLWEDFSGY AMAAAEAQGE QEDSLEKVIK DTESLFKTRE KEYQETIDQI ELELATAKND MNRHLHEYME MCSMKRGLDV QMETCRRLIT QSGDRKSPAF TAVPLSDPPP PPSEAEDSDR DVSSDSSMR |
| 分子量 | 61.9 kDa |
| 蛋白标签 | His tag C-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为假设性文献示例(注：HOM-TES-103蛋白研究信息有限，部分内容为模拟生成，建议通过学术数据库核实)：
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1. **文献名称**：*Recombinant Human HOM-TES-103 Protein Expression and Purification in E. coli*
**作者**：Zhang L, et al.
**摘要**：研究通过大肠杆菌表达系统成功制备重组HOM-TES-103蛋白，优化了诱导条件及纯化工艺，获得高纯度活性蛋白，并验证其抗原性，为后续抗体开发奠定基础。
2. **文献名称**：*HOM-TES-103 as a Potential Tumor Biomarker: Insights from Recombinant Protein-based Serological Assays*
**作者**：Smith J, et al.
**摘要**：利用重组HOM-TES-103蛋白建立ELISA检测方法，发现其在多种癌症患者血清中高表达，提示其可能作为新型肿瘤标志物，具有临床诊断潜力。
3. **文献名称**：*Structural and Functional Characterization of HOM-TES-103 in Cell Adhesion*
**作者**：Wang Y, et al.
**摘要**：通过重组HOM-TES-103蛋白的结构解析及体外实验，揭示其通过整合素信号通路调节细胞黏附和迁移功能，可能参与肿瘤转移过程。
4. **文献名称**：*High-Yield Production of Recombinant HOM-TES-103 in Mammalian Cells and Its Glycosylation Analysis*
**作者**：Kim H, et al.
**摘要**：研究采用哺乳动物细胞表达系统制备重组HOM-TES-103.分析其糖基化修饰对蛋白稳定性的影响，为药物开发提供优化策略。
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建议通过 **PubMed** 或 **Google Scholar** 搜索关键词“HOM-TES-103 protein”或相关疾病背景获取真实文献。
Recombinant human HOM-TES-103 protein is a genetically engineered protein derived from the HOM-TES-103 gene, which encodes a cancer/testis antigen (CTA) predominantly expressed in germline cells and aberrantly activated in various malignancies. CTAs like HOM-TES-103 are of significant research interest due to their restricted expression in normal tissues (primarily testis and thymus) and ectopic expression in tumors, making them potential targets for immunotherapy and diagnostic biomarkers. The HOM-TES-103 protein contains conserved structural motifs associated with nucleic acid binding and intracellular signaling, though its precise biological functions remain under investigation.
Studies suggest HOM-TES-103 may play roles in tumorigenesis by modulating cell proliferation, apoptosis, or immune evasion mechanisms. Its selective expression in cancer cells has prompted exploration as a therapeutic target for T-cell-based therapies, cancer vaccines, or antibody-drug conjugates. Recombinant versions of this protein are typically produced in bacterial or mammalian expression systems for functional studies, antibody development, and epitope mapping. Current research focuses on characterizing its immunogenicity, interaction partners, and clinical relevance across cancer types. While still in preclinical stages, HOM-TES-103 exemplifies the broader pursuit of CTAs as tools for precision oncology, balancing tumor specificity with minimal off-target effects in therapeutic applications.
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