| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | HOXA7 |
| Uniprot No | P31268 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-230aa |
| 氨基酸序列 | MSSSYYVNALFSKYTAGASLFQNAEPTSCSFAPNSQRSGYGAGAGAFASTVPGLYNVNSPLYQSPFASGYGLGADAYGNLPCASYDQNIPGLCSDLAKGACDKTDEGALHGAAEANFRIYPWMRSSGPDRKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKDEGPTAAAAPEGAVPSAAATAAADKADEEDDDEEEEDEEE |
| 分子量 | 51.8 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人HOXA7蛋白的3篇虚构参考文献示例，基于典型研究方向概括：
1. **文献名称**：*Cloning and Functional Analysis of Recombinant Human HOXA7 Protein*
**作者**：Zhang L. et al.
**摘要**：研究通过原核表达系统成功克隆并纯化了重组人HOXA7蛋白，验证其DNA结合活性，并发现其通过调控下游靶基因参与胚胎肢体发育。
2. **文献名称**：*HOXA7 Inhibits Epithelial-Mesenchymal Transition in Breast Cancer via Transcriptional Repression*
**作者**：Wang Y. et al.
**摘要**：研究发现重组HOXA7蛋白在乳腺癌细胞中过表达可抑制EMT进程，降低细胞迁移能力，提示其作为肿瘤抑制因子的潜在机制。
3. **文献名称**：*Structural Characterization of Recombinant HOXA7 Homeodomain and Its Interaction with DNA*
**作者**：Smith J.R. & Kumar P.
**摘要**：通过X射线晶体学解析HOXA7同源域结构，揭示其与特定DNA序列结合的分子机制，为设计靶向HOX蛋白的小分子提供理论基础。
4. **文献名称**：*HOXA7 Enhances Neuronal Differentiation of Embryonic Stem Cells Through BMP Signaling*
**作者**：Chen T. et al.
**摘要**：实验证明重组HOXA7蛋白通过激活BMP/Smad通路促进胚胎干细胞向神经元分化，拓展了其在神经发育领域的功能认知。
*注：上述文献为示例性虚构内容，实际研究中需以真实文献为准。*
The HOXA7 protein is a member of the homeobox (HOX) gene family, which plays pivotal roles in regulating embryonic development, particularly in establishing body segmentation and axial patterning. As a transcription factor, HOXA7 contains a highly conserved 60-amino acid homeodomain that enables DNA binding and modulates the expression of target genes involved in cell differentiation, proliferation, and tissue morphogenesis. In humans, the HOXA7 gene is located on chromosome 7p15.2 within the HOXA cluster. Dysregulation of HOXA7 has been implicated in various cancers, including leukemia, breast cancer, and colorectal carcinoma, where it may act as either an oncogene or tumor suppressor depending on cellular context. Recombinant human HOXA7 protein is typically produced via heterologous expression systems (e.g., E. coli or mammalian cells) for functional studies. Researchers utilize this engineered protein to investigate its DNA-binding properties, interaction partners, and regulatory mechanisms in developmental biology and disease models. Recent studies also explore its potential role in stem cell differentiation and tissue regeneration. The availability of recombinant HOXA7 facilitates structural analyses and high-throughput screening for therapeutic agents targeting HOX-related pathologies.
×
