| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | HOXA11 |
| Uniprot No | P31270 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-313aa |
| 氨基酸序列 | MDFDERGPCSSNMYLPSCTYYVSGPDFSSLPSFLPQTPSSRPMTYSYSSNLPQVQPVREVTFREYAIEPATKWHPRGNLAHCYSAEELVHRDCLQAPSAAGVPGDVLAKSSANVYHHPTPAVSSNFYSTVGRNGVLPQAFDQFFETAYGTPENLASSDYPGDKSAEKGPPAATATSAAAAAAATGAPATSSSDSGGGGGCRETAAAAEEKERRRRPESSSSPESSSGHTEDKAGGSSGQRTRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKINRDRLQYYSANPLL |
| 分子量 | 60.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人HOXA11蛋白的3篇代表性文献的简要总结(基于已有研究背景的合理推演，具体文献需根据实际数据库查询验证)：
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1. **文献名称**：**《HOXA11 regulates endometrial stromal cell differentiation via recombinant protein-mediated pathways》**
**作者**：Taylor HS et al.
**摘要**：研究利用重组人HOXA11蛋白在体外模型中证实其通过调控靶基因(如β3-integrin)的表达，促进子宫内膜基质细胞蜕膜化，揭示了其在胚胎着床中的关键作用。
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2. **文献名称**：**《Recombinant HOXA11 inhibits proliferation and invasion in ovarian cancer cells by modulating EMT pathways》**
**作者**：Wong H et al.
**摘要**：通过表达纯化的重组HOXA11蛋白，证明其通过抑制上皮-间质转化(EMT)相关信号通路(如Wnt/β-catenin)，显著降低卵巢癌细胞迁移和侵袭能力。
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3. **文献名称**：**《Structural and functional characterization of recombinant human HOXA11 DNA-binding domain》**
**作者**：Smith J et al.
**摘要**：报道了大肠杆菌系统中重组表达HOXA11蛋白的DNA结合结构域(氨基酸1-136)，并通过凝胶迁移实验(EMSA)揭示了其特异性结合胚胎发育相关基因启动子的分子机制。
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**注**：以上为基于HOXA11已知功能的推演示例，实际文献需通过PubMed或Web of Science以关键词“recombinant HOXA11”或“HOXA11 protein function”检索获取。建议优先筛选近年高影响力期刊(如*Development*、*Human Reproduction*、*Oncogene*)中的研究。
**Background of Recombinant Human HOXA11 Protein**
The HOXA11 protein, encoded by the *HOXA11* gene, belongs to the homeobox (HOX) family of transcription factors, which play pivotal roles in embryonic development, particularly in patterning the anterior-posterior axis and regulating limb, genital, and uterine development. HOXA11 is critical during organogenesis, influencing cellular differentiation, proliferation, and tissue-specific identity. Dysregulation of HOXA11 has been linked to reproductive disorders, such as endometriosis and infertility, as well as certain cancers, where its abnormal expression may drive oncogenic or tumor-suppressive pathways depending on context.
Recombinant human HOXA11 protein is engineered using biotechnological systems (e.g., *E. coli* or mammalian cell lines) to produce a purified, functional form for research. It typically retains the conserved DNA-binding homeodomain, enabling studies on its interaction with target genes or regulatory partners. Researchers utilize this protein to dissect molecular mechanisms in developmental biology, disease pathology, and epigenetic regulation. Additionally, it serves as a tool for drug screening or therapeutic development, aiming to modulate HOXA11-related pathways in conditions like reproductive disorders or malignancies. Its study bridges fundamental biology with translational applications, highlighting its dual role as a developmental regulator and a potential clinical target.
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