| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | HOXC5 |
| Uniprot No | Q00444 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-222aa |
| 氨基酸序列 | MSSYVANSFYKQSPNIPAYNMQTCGNYGSASEVQASRYCYGGLDLSITFPPPAPSNSLHGVDMAANPRAHPDRPACSAAAAPGHAPGRDEAAPLNPGMYSQKAARPALEERAKSSGEIKEEQAQTGQPAGLSQPPAPPQIYPWMTKLHMSHETDGKRSRTSYTRYQTLELEKEFHFNRYLTRRRRIEIANNLCLNERQIKIWFQNRRMKWKKDSKMKSKEAL |
| 分子量 | 51.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
1. **"HOXC5 promotes leukemogenesis through regulation of CDK6 and cell cycle progression"**
- Author: Zhang, Y. et al.
- 摘要：研究揭示了HOXC5在急性髓系白血病中的致癌作用，通过重组HOXC5蛋白实验证明其结合CDK6启动子并激活表达，促进细胞周期进展和增殖。
2. **"Structural analysis of human HOXC5 DNA-binding domain and its interaction with target sequences"**
- Author: Lee, S. & Patel, D.
- 摘要：通过X射线晶体学解析了重组HOXC5蛋白的DNA结合结构域，揭示了其与特定DNA基序的结合模式，为HOX蛋白的靶向调控机制提供结构基础。
3. **"HOXC5 suppresses epithelial-mesenchymal transition in colorectal cancer by regulating E-cadherin"**
- Author: Chen, L. et al.
- 摘要：研究发现重组HOXC5蛋白在结直肠癌细胞中过表达可上调E-cadherin，抑制EMT过程和肿瘤转移，提示其作为抑癌因子的潜力。
4. **"Recombinant HOXC5 enhances osteogenic differentiation of mesenchymal stem cells via BMP signaling"**
- Author: Gupta, R. et al.
- 摘要：实验表明重组HOXC5蛋白通过激活BMP/Smad通路促进间充质干细胞向成骨细胞分化，为骨组织工程提供了潜在分子工具。
(注：上述文献为模拟示例，实际研究需通过学术数据库验证。)
Recombinant human HOXC5 protein is a genetically engineered version of the HOXC5 transcription factor, which belongs to the homeobox (HOX) gene family. HOX genes are evolutionarily conserved regulators of embryonic development, particularly in establishing body patterning, cell differentiation, and tissue identity. HOXC5. located on chromosome 12. encodes a DNA-binding protein that interacts with specific target genes to modulate cellular processes such as proliferation, apoptosis, and morphogenesis. Dysregulation of HOXC5 has been implicated in various cancers, including leukemia, breast cancer, and colorectal carcinoma, where it may act as either an oncogene or tumor suppressor depending on cellular context.
The recombinant form is typically produced in expression systems like *E. coli* or mammalian cells, enabling researchers to study its structure, biochemical properties, and functional mechanisms *in vitro*. Its production allows for standardized, high-purity samples essential for experiments exploring HOXC5's role in developmental biology, cancer progression, and potential therapeutic applications. Current research focuses on its interactions with signaling pathways (e.g., Wnt, TGF-β), epigenetic regulation, and utility in regenerative medicine models. As an engineered protein, it also serves as a tool for drug screening aimed at modulating HOX-related disorders. Studies using recombinant HOXC5 continue to clarify its dual roles in development and disease, highlighting its importance as a biomedical research target.
×
