| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | HOXC13 |
| Uniprot No | P31276 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-330aa |
| 氨基酸序列 | MTTSLLLHPRWPESLMYVYEDSAAESGIGGGGGGGGGGTGGAGGGCSGASPGKAPSMDGLGSSCPASHCRDLLPHPVLGRPPAPLGAPQGAVYTDIPAPEAARQCAPPPAPPTSSSATLGYGYPFGGSYYGCRLSHNVNLQQKPCAYHPGDKYPEPSGALPGDDLSSRAKEFAFYPSFASSYQAMPGYLDVSVVPGISGHPEPRHDALIPVEGYQHWALSNGWDSQVYCSKEQSQSAHLWKSPFPDVVPLQPEVSSYRRGRKKRVPYTKVQLKELEKEYAASKFITKEKRRRISATTNLSERQVTIWFQNRRVKEKKVVSKSKAPHLHST |
| 分子量 | 62.7 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人HOXC13蛋白的3篇参考文献(人工模拟示例，非真实文献)：
1. **文献名称**：*HOXC13 regulates keratinocyte proliferation and differentiation in human hair follicle development*
**作者**：Zhang Y, et al.
**摘要**：研究通过重组人HOXC13蛋白体外实验，发现其通过激活WNT/β-catenin通路调控毛囊角质形成细胞的增殖与分化，揭示了HOXC13在毛发发育中的关键作用。
2. **文献名称**：*Recombinant HOXC13 protein inhibits tumor growth by suppressing epithelial-mesenchymal transition in squamous cell carcinoma*
**作者**：Li J, Wang X.
**摘要**：研究利用重组HOXC13蛋白处理口腔鳞癌细胞，发现其能抑制肿瘤细胞迁移和侵袭，机制可能与阻断EMT(上皮-间质转化)过程相关，提示HOXC13的潜在抑癌功能。
3. **文献名称**：*Structural and functional analysis of the human HOXC13 transcription factor*
**作者**：Chen R, et al.
**摘要**：通过重组表达并纯化HOXC13蛋白，解析其DNA结合结构域的三维结构，结合染色质免疫沉淀(ChIP)实验证实其特异性靶向毛发角蛋白基因启动子区域。
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注：以上文献为示例，实际研究请通过PubMed、Google Scholar等平台检索。
HOXC13. a member of the homeobox (HOX) gene family, encodes a transcription factor critical for regulating developmental processes, particularly in epithelial appendages like hair follicles, nails, and glands. It plays a key role in cell differentiation, morphogenesis, and tissue patterning by binding DNA to control target gene expression. HOXC13 mutations are linked to hereditary hair/nail disorders, such as pure hair-nail ectodermal dysplasia, highlighting its importance in keratinization and structural integrity.
Recombinant human HOXC13 protein is engineered in vitro using expression systems (e.g., bacterial, mammalian) to produce functional HOXC13 for research. This protein retains DNA-binding activity, enabling studies on its molecular interactions, regulatory networks, and disease mechanisms. Researchers use it to explore HOXC13's role in developmental biology, regenerative medicine, and pathologies like cancer, where dysregulated HOXC13 expression correlates with tumor progression.
Its applications span elucidating genetic pathways in hair follicle cycling, identifying therapeutic targets for congenital disorders, and modeling HOXC13-associated cancers. By providing a purified, active form of the protein, recombinant HOXC13 accelerates mechanistic insights and potential clinical translations in both developmental and disease contexts.
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