| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | RBM35B |
| Uniprot No | Q9H6T0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-727 aa |
| 活性数据 | MTPPPPPPPP PGPDPAADPA ADPCPWPGSL VVLFGATAGA LGRDLGSDET DLILLVWQVV EPRSRQVGTL HKSLVRAEAA ALSTQCREAS GLSADSLARA EPLDKVLQQF SQLVNGDVAL LGGGPYMLCT DGQQLLRQVL HPEASRKNLV LPDMFFSFYD LRREFHMQHP STCPARDLTV ATMAQGLGLE TDATEDDFGV WEVKTMVAVI LHLLKEPSSQ LFSKPEVIKQ KYETGPCSDS TVPCPYSSKA DVVDSETVVR ARGLPWQSSD QDVARFFKGL NVARGGVALC LNAQGRRNGE ALIRFVDSEQ RDLALQRHKH HMGVRYIEVY KATGEEFVKI AGGTSLEVAR FLSREDQVIL RLRGLPFSAG PTDVLGFLGP ECPVTGGTEG LLFVRHPDGR PTGDAFALFA CEELAQAALR RHKGMLGKRY IELFRSTAAE VQQVLNRYAS GPLLPTLTAP LLPIPFPLAP GTGRDCVRLR GLPYTATIED ILSFLGEAAA DIRPHGVHMV LNQQGRPSGD AFIQMTSAER ALAAAQRCHK KVMKERYVEV VPCSTEEMSR VLMGGTLGRS GMSPPPCKLP CLSPPTYTTF QATPTLIPTE TAALYPSSAL LPAARVPAAP TPVAYYPGPA TQLYLNYTAY YPSPPVSPTT VGYLTTPTAA LASAPTSVLS QSGALVRMQG VPYTAGMKDL LSVFQAYQLP ADDYTSLMPV GDPPRTVLQA PKEWVCL |
| 分子量 | 78.4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人RBM35B蛋白的研究，目前公开数据库(如PubMed、Google Scholar)中该名称的文献较少，可能涉及名称拼写误差或研究尚不充分。以下为假设性示例参考文献(非真实存在，仅供格式参考)：
1. **标题**：RBM35B在TGF-β信号通路中的调控作用
**作者**：Zhang L, et al.
**摘要**：研究发现RBM35B通过与SMAD蛋白相互作用，增强TGF-β信号传导，促进上皮-间质转化(EMT)，可能参与肿瘤转移。
2. **标题**：RBM35B的晶体结构解析及其RNA结合特性
**作者**：Wang Y, et al.
**摘要**：通过X射线衍射解析了RBM35B的RNA识别基序(RRM)结构，证实其在mRNA剪接中的关键作用，并揭示了突变对功能的影响。
3. **标题**：RBM35B在肝癌中的异常表达及临床意义
**作者**：Chen H, et al.
**摘要**：免疫组化分析显示，RBM35B在肝癌组织中高表达，与患者生存率负相关，提示其作为潜在预后标志物的可能性。
**注意事项**：
- RBM35B可能为RGMB(Repulsive Guidance Molecule B)或其他名称的误写，建议核实基因名称(如HGNC数据库)。
- 若需真实文献，请提供更准确的蛋白名称或相关功能描述。
**Background of Recombinant Human RBM35B Protein**
Recombinant human RBM35B (RNA-binding motif protein 35B) is a protein encoded by the *RBM35B* gene, which belongs to the RNA-binding motif (RBM) family. This family is characterized by conserved RNA-binding domains (RBDs), critical for interactions with RNA molecules. RBM35B contains typical structural features, such as RNA recognition motifs (RRMs), enabling its role in post-transcriptional regulation, including RNA splicing, stability, and translation.
While RBM35B’s precise biological functions remain understudied, it shares homology with other RBM proteins involved in cellular processes like mRNA processing, apoptosis, and stress responses. Emerging studies suggest potential roles in disease contexts, particularly cancers, where dysregulation of RNA-binding proteins often contributes to tumorigenesis. The recombinant form of RBM35B is produced via genetic engineering in systems like *E. coli* or mammalian cells, ensuring high purity and activity for experimental use.
Research on recombinant RBM35B aids in elucidating its molecular interactions, structural dynamics, and functional pathways. Its study may provide insights into RNA metabolism defects linked to genetic disorders or cancer progression. However, comprehensive mechanistic details and clinical relevance require further exploration. The availability of recombinant RBM35B facilitates targeted studies, positioning it as a potential biomarker or therapeutic candidate in RNA-related pathologies.
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