| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | RBM41 |
| Uniprot No | Q96IZ5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-413 aa |
| 活性数据 | MKRVNSCVKS DEHVLEELET EGERQLKSLL QHQLDTSVSI EECMSKKESF APGTMYKPFG KEAAGTMTLS QFQTLHEKDQ ETASLRELGL NETEILIWKS HVSGEKKTKL RATPEAIQNR LQDIEERISE RQRILCLPQR FAKSKQLTRR EMEIEKSLFQ GADRHSFLKA LYYQDEPQKK NKGDPMNNLE SFYQEMIMKK RLEEFQLMRG EPFASHSLVS ATSVGDSGTA ESPSLLQDKG KQAAQGKGPS LHVANVIDFS PEQCWTGPKK LTQPIEFVPE DEIQRNRLSE EEIRKIPMFS SYNPGEPNKV LYLKNLSPRV TERDLVSLFA RFQEKKGPPI QFRMMTGRMR GQAFITFPNK EIAWQALHLV NGYKLHGKIL VIEFGKNKKQ RSNLQATSLI SCATGSTTEI SGS |
| 分子量 | 47.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是基于模拟数据整理的重组人RBM41蛋白相关文献示例。由于当前关于RBM41的研究较少，以下内容为假设性参考，建议通过权威数据库(如PubMed、Web of Science)进一步核实：
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1. **文献名称**: "Structural and Functional Analysis of Recombinant Human RBM41 in RNA Splicing"
**作者**: Chen, L. et al.
**摘要**: 本研究首次在大肠杆菌中重组表达了人RBM41蛋白，并解析了其RNA结合结构域的晶体结构。研究发现，RBM41通过与剪接复合体组分相互作用，调控特定pre-mRNA的剪接效率，提示其在转录后修饰中的潜在作用。
2. **文献名称**: "RBM41 Knockdown Alters Neuronal mRNA Stability in Neurodegenerative Models"
**作者**: Müller, S. & Zhang, Y.
**摘要**: 利用HEK293细胞表达重组RBM41蛋白，验证了其与神经元特异性RNA的结合能力。实验表明，RBM41通过维持mRNA稳定性影响神经退行性疾病相关蛋白的表达，可能成为治疗靶点。
3. **文献名称**: "High-Throughput Screening of RBM41 Interactions Using Recombinant Protein Arrays"
**作者**: Kim, J. et al.
**摘要**: 本研究开发了重组RBM41的蛋白芯片技术，系统筛选了其与RNA及蛋白的相互作用网络。数据表明，RBM41在细胞应激反应中与多个RNA代谢通路蛋白(如HNRNPA1)存在交叉调控。
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**注意**：上述文献信息为模拟生成，真实研究数据可能有限。建议通过以下方式获取最新信息：
1. 在PubMed中以“RBM41 recombinant”或“RBM41 RNA-binding”为关键词检索。
2. 查阅预印本平台(如bioRxiv)获取未发表成果。
3. 联系相关领域专家或研究组咨询最新进展。
RBM41 (RNA-Binding Motif Protein 41) is a less-characterized member of the RNA-binding protein family, primarily recognized for its role in RNA metabolism and post-transcriptional regulation. Encoded by the RBM41 gene in humans, this protein contains a conserved RNA recognition motif (RRM), a hallmark of proteins involved in RNA processing, stability, and interaction. Although its precise molecular mechanisms remain under investigation, RBM41 is implicated in pre-mRNA splicing, potentially influencing the selection of splice sites or assembly of spliceosomal complexes. Emerging studies suggest its involvement in cellular stress responses, particularly under conditions like DNA damage or oxidative stress, where it may modulate RNA fate decisions.
RBM41 has been detected in various tissues, with higher expression levels observed in the brain, hinting at potential roles in neurodevelopment or neurological disorders. Dysregulation of RBM41 has been tentatively linked to cancer progression, though specific pathways remain unclear. Recent proteomic analyses also associate it with RNA granules, including stress granules and P-bodies, emphasizing its participation in dynamic RNA-protein assemblies. Recombinant RBM41 protein is typically produced in bacterial or mammalian expression systems for structural and functional studies, enabling exploration of its RNA-binding specificity and interaction networks. Current research focuses on elucidating its physiological targets, regulatory partners, and therapeutic potential in diseases marked by RNA processing defects. Despite progress, RBM41's full biological significance awaits further mechanistic and in vivo validation.
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