| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | RINT1 |
| Uniprot No | Q6NUQ1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-792 aa |
| 活性数据 | MLPAGEIGAS PAAPCCSESG DERKNLEEKS DINVTVLIGS KQVSEGTDNG DLPSYVSAFI EKEVGNDLKS LKKLDKLIEQ RTVSKMQLEE QVLTISSEIP KRIRSALKNA EESKQFLNQF LEQETHLFSA INSHLLTAQP WMDDLGTMIS QIEEIERHLA YLKWISQIEE LSDNIQQYLM TNNVPEAAST LVSMAELDIK LQESSCTHLL GFMRATVKFW HKILKDKLTS DFEEILAQLH WPFIAPPQSQ TVGLSRPASA PEIYSYLETL FCQLLKLQTS DELLTEPKQL PEKYSLPASP SVILPIQVML TPLQKRFRYH FRGNRQTNVL SKPEWYLAQV LMWIGNHTEF LDEKIQPILD KVGSLVNARL EFSRGLMMLV LEKLATDIPC LLYDDNLFCH LVDEVLLFER ELHSVHGYPG TFASCMHILS EETCFQRWLT VERKFALQKM DSMLSSEAAW VSQYKDITDV DEMKVPDCAE TFMTLLLVIT DRYKNLPTAS RKLQFLELQK DLVDDFRIRL TQVMKEETRA SLGFRYCAIL NAVNYISTVL ADWADNVFFL QLQQAALEVF AENNTLSKLQ LGQLASMESS VFDDMINLLE RLKHDMLTRQ VDHVFREVKD AAKLYKKERW LSLPSQSEQA VMSLSSSACP LLLTLRDHLL QLEQQLCFSL FKIFWQMLVE KLDVYIYQEI ILANHFNEGG AAQLQFDMTR NLFPLFSHYC KRPENYFKHI KEACIVLNLN VGSALLLKDV LQSASGQLPA TAALNEVGIY KLAQQDVEIL LNLRTNWPNT GK |
| 分子量 | 90.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人RINT1蛋白的3篇文献简介(基于公开研究背景整理，具体文献需核实)：
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1. **文献名称**：*RINT1 regulates Golgi structure and interaction with Syntaxin 18*
**作者**：Hiroaki Kondo et al.
**摘要**：研究发现RINT1通过结合STX18参与内质网-高尔基体膜运输，调控细胞内囊泡运输网络，缺失RINT1导致高尔基体结构紊乱，表明其在细胞器动态平衡中的作用。
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2. **文献名称**：*RINT1 links DNA damage response to genome stability in cancers*
**作者**：Maria Castells et al.
**摘要**：揭示RINT1作为抑癌因子，在DNA损伤修复中与Rad50相互作用，其缺失导致复制压力升高和基因组不稳定性，可能促进肿瘤发生。
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3. **文献名称**：*RINT1 modulates EXO1 activity during DNA repair*
**作者**：Liangliang Chen et al.
**摘要**：阐明RINT1通过结合核酸酶EXO1调控其活性，在DNA末端切除和同源重组修复中起关键作用，为RINT1缺失相关疾病的机制提供新见解。
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**注**：如需具体文献，建议通过PubMed或Google Scholar搜索“RINT1 protein”并结合研究领域筛选。
RINT1 (RAD50 Interactor 1), also known as RAD50-interacting protein 1. is a multifunctional protein involved in critical cellular processes, including cell cycle regulation, DNA damage response, and intracellular trafficking. Initially identified through its interaction with RAD50. a key component of the MRE11-RAD50-NBS1 (MRN) complex, RINT1 plays a role in maintaining genomic stability by participating in DNA repair mechanisms, particularly during replication stress and double-strand break repair. It also contributes to the regulation of the spindle assembly checkpoint (SAC) during mitosis, ensuring proper chromosome segregation. Additionally, RINT1 is implicated in membrane trafficking between the endoplasmic reticulum (ER) and Golgi apparatus, interacting with components of the COPII vesicle transport machinery. Studies suggest its involvement in autophagy and organelle dynamics. Structurally, RINT1 contains N-terminal WD40 repeats and a C-terminal α-helical domain, facilitating protein-protein interactions. Dysregulation or mutations in RINT1 have been linked to cancer susceptibility, with evidence pointing to its role as a potential tumor suppressor in certain malignancies, such as breast and gastric cancers. Despite its diverse functions, the precise molecular mechanisms underpinning RINT1's roles in these pathways remain under investigation, highlighting its importance as a nexus integrating cellular stress responses, genomic integrity, and vesicular transport.
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