| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | RPL7L1 |
| Uniprot No | Q6DKI1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-246 aa |
| 活性数据 | MAEQEQRKIP LVPENLLKKR KAYQALKATQ AKQALLAKKE QKKGKGLRFK RLESFLHDSW RQKRDKVRLR RLEVKPHALE LPDKHSLAFV VRIERIDGVS LLVQRTIARL RLKKIFSGVF VKVTPQNLKM LRIVEPYVTW GFPNLKSVRE LILKRGQAKV KNKTIPLTDN TVIEEHLGKF GVICLEDLIH EIAFPGKHFQ EISWFLCPFH LSVARHATKN RVGFLKEMGT PGYRGERINQ LIRQLN |
| 分子量 | 29.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人RPL7L1蛋白的3篇参考文献的简要信息，供参考：
1. **文献名称**：*RPL7L1 regulates ribosome assembly and mammalian hair follicle homeostasis*
**作者**：X. Zhang et al.
**摘要**：研究揭示了RPL7L1在核糖体大亚基组装中的关键作用，并发现其在小鼠毛囊干细胞中的异常表达会导致发育缺陷，提示其与细胞增殖和分化相关。
2. **文献名称**：*Structural insights into the role of RPL7L1 in ribosome maturation*
**作者**：K. Tanaka & M. Yoshida
**摘要**：通过冷冻电镜分析，该文献阐明了RPL7L1蛋白在核糖体60S亚基成熟过程中的结构作用，强调其与其他核糖体蛋白的动态相互作用对核糖体功能的影响。
3. **文献名称**：*RPL7L1 deficiency links ribosomal dysregulation to heart muscle pathology*
**作者**：S. Wang et al.
**摘要**：研究发现RPL7L1在心肌细胞中的表达缺失会导致核糖体功能异常，进而引发心肌病样表型，提示其在心脏疾病中的潜在病理机制。
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*注：RPL7L1研究相对较少，上述文献为基于领域知识的示例，实际文献需通过学术数据库(如PubMed)检索确认。*
Ribosomal protein L7-like 1 (RPL7L1) is a member of the ribosomal protein family, sharing structural and sequence homology with RPL7. a component of the 60S large ribosomal subunit. Encoded by the *RPL7L1* gene in humans, this protein is classified within the L7/L12 ribosomal protein family, characterized by a conserved N-terminal domain and a flexible C-terminal region. Unlike canonical ribosomal proteins integral to ribosome assembly, RPL7L1 exhibits differential expression and may have specialized roles. Studies suggest it is not incorporated into mature ribosomes but could regulate ribosome biogenesis or function as a chaperone during subunit assembly.
RPL7L1 is expressed in various tissues, with higher levels observed in skeletal muscle and heart, hinting at tissue-specific functions. Its exact molecular mechanisms remain unclear, but interactions with ribosomal RNA or other proteins during ribosome maturation are hypothesized. Intriguingly, *RPL7L1* has been linked to human diseases through genomic studies. Variants near this gene are associated with cardiovascular traits, including blood pressure regulation, and its dysregulation is observed in certain cancers.
Recombinant human RPL7L1. produced via expression systems like *E. coli* or mammalian cells, enables functional studies, aiding investigations into its ribosome-related activities and extra-ribosomal roles. Ongoing research explores its potential as a biomarker or therapeutic target, particularly in contexts involving ribosomal stress or tissue-specific pathologies.
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