关键信息
-
基因名
RING1
- 应用
-
别名
2410018J24Rik; AAP 1; AAP1; APAP 1; APAP-1; APAP1; Apoptin associating protein 1; Apoptin-associating protein 1; cb337; Death effector domain associated factor; Death effector domain-associated factor; Death effector domain-associated factor B; DED associated factor; DED-associated factor; DED-associated factor B; DEDAF; MGC62213; RING1 and YY1 binding protein a; RING1 and YY1 binding protein; RING1 and YY1-binding protein; RING1 and YY1-binding protein B; Ring1 interactor RYBP; RYBP; RYBP_HUMAN; rybpa; wu:fi34f03; YEAF 1; YEAF1; YY1 and E4TF1 associated factor 1; YY1 and E4TF1-associated factor 1; YY1- and E4TF1/GABP-associated factor 1; zgc:153842
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q8N488
-
表达区间
1-228 aa
-
氨基酸序列
MTMGDKKSPT RPKRQAKPAA DEGFWDCSVC TFRNSAEAFK CSICDVRKGT STRKPRINSQ LVAQQVAQQY ATPPPPKKEK KEKVEKQDKE KPEKDKEISP SVTKKNTNKK TKPKSDILKD PPSEANSIQS ANATTKTSET NHTSRPRLKN VDRSTAQQLA VTVGNVTVII TDFKEKTRSS STSSSTVTSS AGSEQQNQSS SGSESTDKGS SRSSTPKGDM SAVNDESF
-
分子量
24.8 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
RING1, a member of the RING finger protein family, has garnered significant attention in the field of molecular biology due to its essential role in various cellular processes, particularly in the regulation of gene expression and chromatin remodeling. Known for its E3 ubiquitin ligase activity, RING1 facilitates the ubiquitination of target proteins, impacting protein degradation and signaling pathways. This function is crucial in developmental processes, cellular differentiation, and the maintenance of stem cell pluripotency. Further, RING1 is a component of the Polycomb Repressive Complex 1 (PRC1), which is involved in transcriptional repression and chromatin organization, making it vital for cellular memory during development. Dysregulation of RING1 has been implicated in various diseases, including cancer, where its aberrant expression can lead to unchecked cell proliferation and survival. Understanding the molecular mechanisms governing RING1 activity and its interactions with other cellular components is crucial for developing potential therapeutic strategies. Recent advances in structural biology and proteomics have provided new insights into RING1’s functional dynamics, driving research aimed at delineating its role in health and disease. Consequently, the study of RING1 not only enhances our understanding of fundamental biological processes but also opens avenues for innovative treatments targeting its pathways in disease contexts.
