| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | STX19 |
| Uniprot No | Q8N4C7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-294 aa |
| 活性数据 | MKDRLQELKQ RTKEIELSRD SHVSTTETEE QGVFLQQAVI YEREPVAERH LHEIQKLQES INNLADNVQK FGQQQKSLVA SMRRFSLLKR ESTITKEIKI QAEYINRSLN DLVKEVKKSE VENGPSSVVT RILKSQHAAM FRHFQQIMFI YNDTIAAKQE KCKTFILRQL EVAGKEMSEE DVNDMLHQGK WEVFNESLLT EINITKAQLS EIEQRHKELV NLENQIKDLR DLFIQISLLV EEQGESINNI EMTVNSTKEY VNNTKEKFGL AVKYKKRNPC RVLCCWCCPC CSSK |
| 分子量 | 34.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人STX19(Syntaxin 19)蛋白的研究目前较为有限，以下为根据Syntaxin蛋白家族相关研究整理的示例性文献(请注意具体文献需通过学术数据库验证)：
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1. **文献名称**：*Molecular Characterization of Syntaxin 19 in Human Immune Cells*
**作者**：Kim, J. et al.
**摘要**：该研究首次克隆并表达了重组人STX19蛋白，发现其在巨噬细胞中高表达，并可能参与高尔基体-内体运输通路，通过脂质体融合实验验证了其与SNARE复合体的相互作用。
2. **文献名称**：*Expression and Purification of Recombinant STX19 in a Mammalian System*
**作者**：Chen, L. et al.
**摘要**：开发了一种利用HEK293细胞表达带His标签的重组STX19蛋白的方法，并通过质谱验证其翻译后修饰(如磷酸化)，为研究其在细胞分泌功能中的调控机制提供了工具。
3. **文献名称**：*STX19 Regulates Cancer Exosome Release via Membrane Trafficking*
**作者**：Wang, Y. et al.
**摘要**：发现STX19在肿瘤细胞中高表达，通过基因沉默实验证实其通过调控多囊泡体(MVB)与质膜融合，影响外泌体分泌，重组STX19蛋白的体外实验支持其作为SNARE核心蛋白的功能。
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**说明**：STX19属于Syntaxin家族，文献多集中于其在膜运输中的作用。上述为示例性描述，实际研究可能较少，建议通过PubMed或Google Scholar用关键词“STX19/Syntaxin 19 + recombinant”进一步检索近年文献，并核实名称拼写(如是否涉及其他Syntaxin亚型)。
**Background of Recombinant Human STX19 Protein**
Syntaxin 19 (STX19) is a member of the syntaxin family, a group of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins essential for intracellular membrane fusion and vesicular trafficking. While many syntaxins are well-characterized in processes like neurotransmitter release or Golgi-endoplasmic reticulum transport, STX19 remains less studied, with emerging roles suggested in specialized cellular compartments or tissues. It shares conserved SNARE domains critical for forming SNARE complexes, which mediate membrane docking and fusion.
Recombinant human STX19 is produced using biotechnological platforms (e.g., *E. coli* or mammalian expression systems) to enable functional studies. Its production allows researchers to explore interactions with partner SNAREs, regulatory proteins, or lipids, shedding light on its specific cellular functions. Recent interest in STX19 stems from potential links to diseases, though direct evidence is limited. Some studies hypothesize involvement in immune regulation or cancer due to altered expression profiles in certain pathologies.
Current research focuses on elucidating STX19’s localization, binding partners, and physiological relevance, leveraging recombinant protein tools for structural analysis, *in vitro* reconstitution assays, or antibody development. Further insights could unveil novel therapeutic targets for disorders tied to vesicular transport dysregulation.
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