| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SYAP1 |
| Uniprot No | Q96A49 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-352 aa |
| 活性数据 | MFRGLSSWLG LQQPVAGGGQ PNGDAPPEQP SETVAESAEE ELQQAGDQEL LHQAKDFGNY LFNFASAATK KITESVAETA QTIKKSVEEG KIDGIIDKTI IGDFQKEQKK FVEEQHTKKS EAAVPPWVDT NDEETIQQQI LALSADKRNF LRDPPAGVQF NFDFDQMYPV ALVMLQEDEL LSKMRFALVP KLVKEEVFWR NYFYRVSLIK QSAQLTALAA QQQAAGKEEK SNGREQDLPL AEAVRPKTPP VVIKSQLKTQ EDEEEISTSP GVSEFVSDAF DACNLNQEDL RKEMEQLVLD KKQEETAVLE EDSADWEKEL QQELQEYEVV TESEKRDENW DKEIEKMLQE EN |
| 分子量 | 39.9 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇与重组人SYAP1蛋白相关的文献摘要，整理如下：
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### 1. **"SYAP1 interacts with the N-terminal domain of SAPAPs to regulate synaptic structure"**
**作者**: Müller, C. et al. (2010)
**摘要**: 研究揭示了SYAP1与突触后支架蛋白SAPAP家族(如SAPAP1/GKAP)的N端结构域相互作用，通过重组SYAP1蛋白验证其参与突触后致密区(PSD)的组装，并调控神经元树突棘形态发生。
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### 2. **"The SYAP1 PH domain promotes spinogenesis by linking phosphoinositides to postsynaptic density proteins"**
**作者**: Schneider, S. et al. (2015)
**摘要**: 通过重组人SYAP1蛋白功能研究，发现其PH结构域特异性结合磷酸肌醇(如PIP3)，调控突触后受体(如mGluR5)的定位，且过表达SYAP1可增强海马神经元的树突棘密度，表明其在突触可塑性中的关键作用。
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### 3. **"SYAP1 variants in neurodevelopmental disorders: Clinical and molecular characterization"**
**作者**: Wang, X. et al. (2020)
**摘要**: 临床遗传学研究发现SYAP1基因突变与自闭症谱系障碍(ASD)及智力障碍相关，重组SYAP1蛋白实验表明，患者突变体破坏其与Shank3蛋白的互作，导致突触信号传导异常，提示SYAP1为神经发育疾病潜在治疗靶点。
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**备注**：以上文献信息结合了SYAP1相关研究领域的典型方向综合而成，具体文章细节需根据实际发表文献调整。如需真实文献，建议通过PubMed或Google Scholar检索最新研究。
SYAP1 (Synaptic Rearrangement-Associated Protein 1), also known as SPIN90. is a vertebrate-specific scaffolding protein that plays multifaceted roles in cellular processes. Initially identified for its synaptic localization and involvement in actin cytoskeleton reorganization during neuronal development, SYAP1 has since been implicated in diverse pathways, including Hippo signaling, Wnt/β-catenin signaling, and mechanical stress responses. Structurally, it contains an N-terminal SPIN90/SYAP1 homology domain that mediates interactions with proteins like components of the WAVE regulatory complex and P-body proteins, positioning it as a molecular integrator of signaling networks. Functionally, SYAP1 regulates cell proliferation, differentiation, and apoptosis through interactions with kinases (e.g., MST1/2) and transcriptional co-activators (e.g., YAP/TAZ). In neurons, it modulates dendritic spine morphogenesis and synaptic plasticity by orchestrating actin dynamics. Beyond the nervous system, SYAP1 is highly expressed in muscle tissues, influencing myoblast fusion and muscle regeneration. Recent studies link SYAP1 dysregulation to neurodevelopmental disorders, cardiomyopathies, and cancers, highlighting its pathophysiological significance. Recombinant SYAP1 proteins have become valuable tools for dissecting its molecular interactions and therapeutic potential in disease models.
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