Recombinant Human LEI protein

中文名： 白细胞弹性蛋白酶抑制因子(LEI)重组蛋白
别名： LEI；ELANH2；MNEI；PI2；Leukocyte elastase inhibitor

货号: PA1000-8047

Price： ￥询价

20μg 50μg 100μg ＞100μg

数量：

大包装询价

产品详情

纯度	>90%SDS-PAGE.
种属	Human
靶点	LEI
Uniprot No	P30740
内毒素	< 0.01EU/μg
表达宿主	E.coli
表达区间	1-379aa
氨基酸序列	MEQLSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFNTVEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMLMPEENFTADHPFLFFIRHNSSGSILFLGRFSSP
预测分子量	58.7kDa
蛋白标签	His tag N-Terminus
缓冲液	PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于LEI(Lepidopteran Expressed Inhibitor)重组蛋白的3篇参考文献示例，基于常见研究方向整理：

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1. **文献名称**: "Expression and Functional Characterization of Recombinant LEI Protein in Insect Cells"

**作者**: Zhang, Y., et al.

**摘要**: 本研究利用杆状病毒表达系统在昆虫细胞中高效表达了重组LEI蛋白，证实其具有抑制特定丝氨酸蛋白酶活性的功能，为开发新型害虫控制剂提供了基础。

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2. **文献名称**: "Structural Insights into LEI Recombinant Protein as a Potential Antiviral Agent"

**作者**: Wang, L., et al.

**摘要**: 通过X射线晶体学解析了重组LEI蛋白的三维结构，发现其与病毒包膜蛋白存在特异性结合，实验证明其可抑制病毒入侵宿主细胞，具有抗病毒药物开发潜力。

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3. **文献名称**: "LEI Recombinant Protein Enhances Immune Response in Vaccine Adjuvant Studies"

**作者**: Gupta, R., et al.

**摘要**: 评估了重组LEI蛋白作为疫苗佐剂的免疫增强效果，结果表明其能显著提高模型抗原的细胞和体液免疫应答，提示其在疫苗设计中的潜在应用价值。

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注：若“LEI”指代其他特定蛋白(如凋亡相关LEI/L-DNase II)，建议提供更完整名称以便精准检索。上述内容为模拟示例，实际文献需通过学术数据库核实。

背景信息

**Background of LEI Recombinant Protein**

Recombinant proteins, including LEI (Lombard Emergency Initiative) recombinant protein, are engineered through genetic modification techniques to produce specific proteins in host organisms (e.g., bacteria, yeast, or mammalian cells). The LEI protein, originally identified for its role in cellular stress responses, has garnered attention due to its potential applications in biomedical research and therapeutic development.

The LEI gene encodes a protein involved in modulating intracellular pathways, particularly those linked to apoptosis, inflammation, and immune regulation. By leveraging recombinant DNA technology, scientists can produce LEI protein in vitro with high purity and consistency. This process involves cloning the LEI gene into an expression vector, introducing it into a host system, and purifying the expressed protein for downstream use.

LEI recombinant protein is valued for its structural and functional fidelity to the native protein, enabling researchers to study its interactions with cellular components, receptors, or signaling molecules. Its applications span drug discovery, vaccine development, and diagnostic tool design. For instance, LEI protein may serve as a biomarker for certain diseases or act as a therapeutic agent to modulate immune responses in autoimmune disorders or cancer.

Advancements in recombinant technology have enhanced the scalability and cost-effectiveness of LEI protein production, making it accessible for both academic and industrial research. Ongoing studies focus on optimizing its stability, delivery mechanisms, and therapeutic efficacy in preclinical models.

In summary, LEI recombinant protein exemplifies the intersection of molecular biology and translational medicine, offering a versatile tool to unravel disease mechanisms and accelerate the development of targeted therapies. Its continued exploration holds promise for addressing unmet medical needs in diverse pathological contexts.