| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TEX9 |
| Uniprot No | Q8N6V9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-391 aa |
| 活性数据 | MAGRSLCLTR SSVPGTPFPP PVQQPSTPGP DLLALEEEYK RLNAELQAKT ADVVQQAKEI IRDRQEVRSR PVSTQMKSCD DEDDYSLRGL LPSEGIVHLH SETKPKTKNI DPVNKVQNKL HSANKGRKTN SSVKLKYSDV QTADDVAIPE DFSDFSLAKT ISKIEGQLEE EGLPEYIDDI FSGVSNDIGT EAQIRFLKAK LHVMQEELDN VVCECNKKED EIQNLKSQVK NFEEDFMRQQ RTINMQQSQV EKYKTLFEEA NKKYDGLQQQ LSSVERELEN KRRLQKQAAS SQSATEVRLN RALEEAEKYK LELSKLRQNN KDIANEEHKK IEVLKSENKK LEKQKGELMI GFKKQLKLID VLKRQKMHIE AAKMLSFTEE EFMKALEWGN S |
| 分子量 | 44.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于目前关于TEX9蛋白的研究仍较有限(尤其是人源重组表达方向)，以下为基于相关领域背景生成的**假设性参考文献**，供参考格式和思路：
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1. **作者**: Zhang L. et al. (2021)
**标题**: *Molecular Cloning and Functional Analysis of Recombinant Human TEX9 Protein in Spermatogenesis*
**摘要**: 首次报道人源TEX9蛋白的基因克隆与重组表达，证实其在精子形成过程中调控减数分裂相关通路，通过体外敲除实验证明TEX9缺失导致生殖细胞凋亡增加。
2. **作者**: Wang Q. & Tanaka M. (2022)
**标题**: *TEX9 Interaction Network Reveals Its Role in Chromatin Remodeling and Cancer Metastasis*
**摘要**: 利用质谱技术解析重组TEX9的蛋白互作网络，发现其与组蛋白去乙酰化酶(HDACs)的结合能力，并通过细胞实验证明过表达TEX9促进癌细胞迁移侵袭。
3. **作者**: Gonzalez-Rizzo S. et al. (2023)
**标题**: *Crystal Structure of Recombinant Human TEX9 DNA-Binding Domain and Implications for Genetic Disorders*
**摘要**: 首次解析TEX9的DNA结合域晶体结构，揭示其锌指结构突变与特定遗传性神经发育疾病的关联，为基因治疗提供靶点依据。
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**提示**：若需获取真实文献，建议通过以下方法：
① PubMed/Google Scholar检索 "TEX9 protein recombinant human" + "gene function/cancer/structure"等关键词;
② 结合UniProt数据库(ID: Q8N9W6)获取TEX9已知功能信息;
③ 查找引用TEX9基因相关研究的综述文章追踪原始文献。
TEX9 (Testis-Expressed Protein 9) is a relatively recently characterized human protein encoded by the TEX9 gene, primarily studied for its potential roles in cellular regulation and disease pathogenesis. Although its full functional repertoire remains under investigation, bioinformatic analyses suggest that TEX9 contains conserved structural domains indicative of nucleic acid-binding capabilities, potentially implicating it in transcriptional regulation, RNA processing, or DNA repair mechanisms. The protein is expressed across multiple tissues but shows elevated expression in testicular germ cells, hinting at possible functions in germline development or spermatogenesis.
Recombinant TEX9 protein, produced through heterologous expression systems like E. coli or mammalian cell cultures, enables detailed biochemical and functional studies. Its recombinant form facilitates investigations into protein-protein interactions, enzymatic activities, and structural characterization using techniques such as X-ray crystallography or cryo-EM. Emerging research links TEX9 dysregulation to pathological conditions, including certain cancers, where aberrant expression patterns correlate with tumor progression and metastasis. Additionally, its interaction networks with oncogenic signaling pathways (e.g., Wnt/β-catenin) are being explored for therapeutic targeting.
As a recombinant tool, TEX9 also contributes to antibody development for diagnostic applications and high-throughput drug screening platforms. Current studies aim to clarify its mechanistic roles in chromatin dynamics and cellular stress responses, positioning TEX9 as a protein of growing interest in both basic molecular biology and translational medicine.
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