| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF157 |
| Uniprot No | P51786 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-506 aa |
| 活性数据 | MPANGTSPQR FPALIPGEPG RSFEGSVSFE DVAVDFTRQE WHRLDPAQRT MHKDVMLETY SNLASVGLCV AKPEMIFKLE RGEELWILEE ESSGHGYSGS LSLLCGNGSV GDNALRHDND LLHHQKIQTL DQNVEYNGCR KAFHEKTGFV RRKRTPRGDK NFECHECGKA YCRKSNLVEH LRIHTGERPY ECGECAKTFS ARSYLIAHQK THTGERPFEC NECGKSFGRK SQLILHTRTH TGERPYECTE CGKTFSEKAT LTIHQRTHTG EKPYECSECG KTFRVKISLT QHHRTHTGEK PYECGECGKN FRAKKSLNQH QRIHTGEKPY ECGECGKFFR MKMTLNNHQR THTGEKPYQC NECGKSFRVH SSLGIHQRIH TGEKPYECNE CGNAFYVKAR LIEHQRMHSG EKPYECSECG KIFSMKKSLC QHRRTHTGEK PYECSECGNA FYVKVRLIEH QRIHTGERPF ECQECGKAFC RKAHLTEHQR THIGWSWRCT MKKASH |
| 分子量 | 58.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZNF157蛋白的假设参考文献示例(文献为虚构，仅作格式参考)：
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1. **文献名称**: *Cloning and expression analysis of ZNF157 in neural tumors*
**作者**: Schultz et al. (1996)
**摘要**: 首次报道ZNF157基因的克隆及重组蛋白表达，发现其在神经母细胞瘤中高表达，提示其可能参与神经发育或肿瘤发生。
2. **文献名称**: *Structural characterization of the ZNF157 protein domain*
**作者**: van Belzen et al. (1997)
**摘要**: 解析ZNF157蛋白的锌指结构域，并通过重组蛋白实验证明其具有DNA结合活性，推测其在基因转录调控中发挥作用。
3. **文献名称**: *ZNF157 inhibits neuronal differentiation via epigenetic regulation*
**作者**: Yamada et al. (2003)
**摘要**: 利用重组ZNF157蛋白探究功能，发现其通过与染色质修饰复合物相互作用，抑制神经干细胞向成熟神经元的分化。
4. **文献名称**: *Proteomic screening of ZNF157 interaction network*
**作者**: Smith et al. (2015)
**摘要**: 通过重组ZNF157蛋白进行蛋白质互作组学分析，揭示其与多种转录因子及表观遗传调控因子的关联，拓展对其功能机制的理解。
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注：以上文献为假设性示例，实际研究中建议通过PubMed或Google Scholar检索真实文献。
**Background of Recombinant Human ZNF157 Protein**
Zinc finger protein 157 (ZNF157), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family, is encoded by the *ZNF157* gene located on human chromosome X. Characterized by tandem C2H2-type zinc finger motifs, ZNF157 is postulated to function as a transcriptional regulator, mediating sequence-specific DNA binding and protein interactions, potentially influencing gene expression and chromatin remodeling. The KRAB domain, a hallmark of this protein family, often recruits co-repressors to inhibit transcription, suggesting ZNF157 may play roles in transcriptional repression or epigenetic silencing.
While the biological functions of ZNF157 remain less explored compared to other ZNF family members, studies indicate its expression in neural tissues and germ cells, implicating possible roles in neurodevelopment, spermatogenesis, or stem cell maintenance. Structural similarities to oncogenic and tumor-suppressive ZNF proteins also hint at potential involvement in cancer progression, though mechanistic insights are limited.
Recombinant human ZNF157 protein, typically produced via heterologous expression systems (e.g., *E. coli* or mammalian cells), enables functional studies, including DNA-binding assays, interaction partner identification, and mechanistic exploration of its regulatory roles. Its recombinant form is crucial for deciphering contributions to cellular processes and diseases, providing a tool for therapeutic target discovery in conditions linked to transcriptional dysregulation. Further research is needed to fully unravel its physiological and pathological significance.
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