Cat: PA2000-3170

Recombinant Human VASH1 Protein,His

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关键信息

  • 基因名

    VASH1

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    VASH1;KIAA1036;VASH;Tubulinyl-Tyr carboxypeptidase 1

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    Q7L8A9

  • 表达区间

    1-204aa

  • 氨基酸序列

    MPGGKKVAGGGSSGATPTSAAATAPSGVRRLETSEGTSAQRDEEPEEEGEEDLRDGGVPFFVNRGGLPVDEATWERMWKHVAKIHPDGEKVAQRIRGATDLPKIPIPSVPTFQPSTPVPERLEAVQRYIRELQYNHTGTQFFEIKKSRPLTGLMDLAKEMTKEALPIKCLEAVILGMYPSSPEGEGSGLLWASASCSESEGGVG

  • 分子量

    27.3 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

VASH1 (Vasohibin-1) is an angiogenic factor that plays a crucial role in the regulation of blood vessel formation and maintenance. It was originally identified for its ability to inhibit endothelial cell proliferation and migration, processes essential for angiogenesis. The significance of VASH1 in vascular biology has led to extensive research into its potential roles in various physiological and pathological conditions, including cancer, ischemic diseases, and wound healing. Emerging studies have highlighted its dual functions, not only as an anti-angiogenic protein but also as a promoter of endothelial cell survival and differentiation in specific contexts. Understanding the molecular mechanisms underlying VASH1’s action could provide insights into novel therapeutic strategies for diseases characterized by abnormal angiogenesis. Furthermore, the recombinant expression of VASH1 has enabled researchers to explore its functional properties in controlled environments, facilitating investigations into its interactions with endothelial cells and other cell types. Characterizing VASH1’s structure and function through recombinant protein studies can pave the way for the development of targeted therapies that manipulate angiogenesis for clinical benefit. These efforts underscore the importance of VASH1 as a potential biomarker and therapeutic target in angiogenesis-related diseases.

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