| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF398 |
| Uniprot No | Q8TD17 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-642 aa |
| 活性数据 | MAEAAPAPTSEWDSECLTSLQPLPLPTPPAANEAHLQTAAISLWTVVAAVQAIERKVEIH SRRLLHLEGRTGTAEKKLASCEKTVTELGNQLEGKWAVLGTLLQEYGLLQRRLENLENLL RNRNFWILRLPPGIKGDIPKVPVAFDDVSIYFSTPEWEKLEEWQKELYKNIMKGNYESLI SMDYAINQPDVLSQIQPEGEHNTEDQAGPEESEIPTDPSEEPGISTSDILSWIKQEEEPQ VGAPPESKESDVYKSTYADEELVIKAEGLARSSLCPEVPVPFSSPPAAAKDAFSDVAFKS QQSTSMTPFGRPATDLPEASEGQVTFTQLGSYPLPPPVGEQVFSCHHCGKNLSQDMLLTH QCSHATEHPLPCAQCPKHFTPQADLSSTSQDHASETPPTCPHCARTFTHPSRLTYHLRVH NSTERPFPCPDCPKRFADQARLTSHRRAHASERPFRCAQCGRSFSLKISLLLHQRGHAQE RPFSCPQCGIDFNGHSALIRHQMIHTGERPYPCTDCSKSFMRKEHLLNHRRLHTGERPFS CPHCGKSFIRKHHLMKHQRIHTGERPYPCSYCGRSFRYKQTLKDHLRSGHNGGCGGDSDP SGQPPNPPGPLITGLETSGLGVNTEGLETNQWYGEGSGGGVL |
| 分子量 | 71.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是三篇关于重组人ZNF398蛋白的参考文献示例(注：文献为假设性描述，实际需核实)：
1. **《ZNF398 regulates TGF-β signaling and epithelial-mesenchymal transition in cancer》**
- 作者：Li, X. et al. (2015)
- 摘要：研究揭示ZNF398通过调控TGF-β信号通路促进上皮-间质转化(EMT)，增强肿瘤细胞的侵袭能力，提示其在癌症转移中的作用机制。
2. **《Structural insights into ZNF398-DNA interactions and functional implications》**
- 作者：Zhang, Y. et al. (2018)
- 摘要：通过X射线晶体学解析ZNF398蛋白的DNA结合结构域，证实其锌指基序特异性识别特定DNA序列，为基因表达调控提供结构基础。
3. **《ZNF398 interacts with p53 and modulates DNA damage response》**
- 作者：Chen, L. et al. (2020)
- 摘要：发现ZNF398与肿瘤抑制因子p53直接结合，参与DNA损伤修复反应，敲除ZNF398导致细胞对放疗敏感性增加，提示其潜在治疗靶点价值。
如需真实文献，建议通过PubMed或Google Scholar检索“ZNF398 protein”或“recombinant ZNF398”获取最新研究。
ZNF398. also known as Zinc Finger Protein 398. is a member of the C2H2-type zinc finger protein family characterized by conserved cysteine and histidine residues that coordinate zinc ions to form structural scaffolds for DNA or RNA binding. This protein is encoded by the human *ZNF398* gene located on chromosome 7q22.1. Functionally, ZNF398 is implicated in transcriptional regulation, chromatin remodeling, and cellular processes such as proliferation, differentiation, and stress response. It acts as a co-regulator, often interacting with other transcription factors or epigenetic modifiers to modulate target gene expression. Studies suggest its involvement in pathways linked to cancer, where dysregulation of ZNF398 may influence tumor progression by altering oncogenic or tumor-suppressive signals. Recombinant human ZNF398 protein is typically produced in heterologous systems (e.g., *E. coli* or mammalian cells) for in vitro studies to dissect its molecular mechanisms, DNA-binding specificity, or interactions. Its recombinant form often includes affinity tags (e.g., GST, His-tag) to facilitate purification and detection. Research on ZNF398 is ongoing, with potential applications in understanding gene regulatory networks, developing biomarkers, or exploring therapeutic targets in diseases associated with transcriptional dysregulation.
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