| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF697 |
| Uniprot No | Q5TEC3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-136 aa |
| 活性数据 | MCSECGETFSVSSHLFTHKRTHSGERPYVCRECGKGFGRNSHLVNHLRVHTGEKPFRCGQCEKRFSDFSTLTQHQRTHTGEKPYTCIECGKSFIQSSHLIRHRRIHTGNKPHKCAGCGKGFRYKTHLAQHQKLHLC |
| 分子量 | 42 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3-4条关于重组人ZNF697蛋白的模拟参考文献(非真实文献，仅供示例参考)：
1. **Title**: "ZNF697 acts as a tumor suppressor in colorectal cancer via transcriptional regulation of cell cycle genes"
**Authors**: Li X, Chen Y, Wang H
**Summary**: 研究发现ZNF697通过结合特定DNA序列抑制细胞周期相关基因(如Cyclin D1)的转录，抑制结直肠癌细胞增殖，且其低表达与患者预后不良相关。
2. **Title**: "Structural insights into the DNA-binding mechanism of ZNF697 zinc finger domains"
**Authors**: Smith J, Brown K, Davis R
**Summary**: 通过X射线晶体学解析ZNF697锌指结构域与DNA复合物的三维结构，揭示其通过多个保守残基与靶基因启动子结合的分子机制。
3. **Title**: "ZNF697 interacts with DNA repair machinery and modulates homologous recombination"
**Authors**: Garcia S, Lee T, Müller P
**Summary**: 研究表明ZNF697与BRCA1等DNA修复蛋白相互作用，在DNA损伤应答中促进同源重组修复，其缺失导致基因组不稳定性增加。
4. **Title**: "Epigenetic silencing of ZNF697 in thyroid carcinoma and its prognostic implications"
**Authors**: Wang L, Zhang Q, Liu F
**Summary**: 揭示甲状腺癌中ZNF697启动子高甲基化导致其表达下调，且与肿瘤转移和患者生存率降低显著相关，提示其作为潜在预后标志物。
注：以上内容为根据领域常见研究方向模拟生成，非真实存在的文献。如需真实文献，建议通过PubMed或Google Scholar以“ZNF697 protein”为关键词检索。
ZNF697. a member of the zinc finger protein family, is a transcription regulatory protein characterized by its C2H2-type zinc finger domains, which enable sequence-specific DNA binding. This protein is encoded by the ZNF697 gene located on human chromosome 7p22.3. As a Kruppel-associated box (KRAB)-containing zinc finger protein, ZNF697 is speculated to function as a transcriptional repressor, potentially involved in chromatin remodeling and gene silencing through interactions with co-repressor complexes. Studies suggest its role in cellular processes like differentiation, proliferation, and apoptosis. Dysregulation of ZNF697 has been observed in certain cancers, including renal cell carcinoma, where its downregulation correlates with tumor progression, hinting at a possible tumor-suppressive function. Recombinant human ZNF697 protein is commonly produced in vitro using expression systems like E. coli or mammalian cells for functional studies, enabling researchers to investigate its DNA-binding specificity, protein-protein interactions, and mechanistic roles in disease pathways. Its recombinant form serves as a critical tool for elucidating molecular mechanisms in epigenetics and cancer biology, with potential applications in therapeutic target discovery and diagnostic biomarker development.
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