| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF692 |
| Uniprot No | Q9BU19 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-519 aa |
| 活性数据 | MASSPAVDVSCRRREKRRQLDARRSKCRIRLGGHMEQWCLLKERLGFSLHSQLAKFLLDRYTSSGCVLCAGPEPLPPKGLQYLVLLSHAHSRECSLVPGLRGPGGQDGGLVWECSAGHTFSWGPSLSPTPSEAPKPASLPHTTRRSWCSEATSGQELADLESEHDERTQEARLPRRVGPPPETFPPPGEEEGEEEEDNDEDEEEMLSDASLWTYSSSPDDSEPDAPRLLPSPVTCTPKEGETPPAPAALSSPLAVPALSASSLSSRAPPPAEVRVQPQLSRTPQAAQQTEALASTGSQAQSAPTPAWDEDTAQIGPKRIRKAAKRELMPCDFPGCGRIFSNRQYLNHHKKYQHIHQKSFSCPEPACGKSFNFKKHLKEHMKLHSDTRDYICEFCARSFRTSSNLVIHRRIHTGEKPLQCEICGFTCRQKASLNWHQRKHAETVAALRFPCEFCGKRFEKPDSVAAHRSKSHPALLLAPQESPSGPLEPCPSISAPGPLGSSEGSRPSASPQAPTLLPQQ |
| 分子量 | 83.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZNF692蛋白研究的虚构示例参考文献，供参考(注：文献为模拟示例，需结合真实数据库查询最新成果)：
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1. **文献名称**: *ZNF692 promotes hepatocellular carcinoma progression via regulating cell cycle pathways*
**作者**: Li, X. et al.
**摘要**: 研究利用重组ZNF692蛋白进行体外功能分析，发现其过表达通过激活CDK4/cyclin D1信号通路加速肝癌细胞G1/S期转换，并促进肿瘤增殖。重组蛋白通过大肠杆菌表达系统纯化后用于抗体验证及下游分子互作实验。
2. **文献名称**: *Structural analysis of recombinant human ZNF692 reveals a novel zinc finger cluster involved in DNA binding*
**作者**: Zhang, Y. et al.
**摘要**: 本研究解析了重组ZNF692蛋白的晶体结构，发现其C端锌指结构域具有独特的空间构象，能够特异性识别富含GC的DNA序列。重组蛋白在昆虫细胞系统中表达并用于体外电泳迁移实验(EMSA)，为转录调控机制提供结构依据。
3. **文献名称**: *Recombinant ZNF692 as a potential biomarker in breast cancer serum detection*
**作者**: Wang, H. et al.
**摘要**: 研究开发了基于哺乳动物细胞表达的重组ZNF692蛋白，建立ELISA检测方法，发现乳腺癌患者血清中ZNF692水平显著升高，与肿瘤侵袭性呈正相关，提示其作为诊断标志物的潜力。
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**建议**：实际文献可通过PubMed、Web of Science等平台，以关键词“recombinant ZNF692”“ZNF692 protein function”等检索，重点关注蛋白表达纯化、结构功能或疾病机制研究。
Zinc finger protein 692 (ZNF692) is a member of the zinc finger protein family, characterized by conserved Cys₂His₂ (C2H2)-type zinc finger domains that facilitate nucleic acid binding and protein interactions. Predominantly localized in the nucleus, ZNF692 is implicated in transcriptional regulation and chromatin remodeling, with potential roles in cell proliferation, differentiation, and oncogenesis. Structurally, it contains multiple zinc finger motifs and nuclear localization signals, suggesting involvement in DNA or RNA interactions. Emerging studies link ZNF692 dysregulation to various cancers, including hepatocellular carcinoma, gastric cancer, and colorectal cancer, where its overexpression or mutations correlate with tumor progression, metastasis, or chemoresistance, though its precise mechanisms remain under investigation. Additionally, ZNF692 may participate in early embryonic development and stem cell maintenance, as evidenced by its expression patterns in pluripotent cells. Recombinant human ZNF692 protein, typically produced via prokaryotic or eukaryotic expression systems, enables functional studies on its biochemical properties, binding partners, and signaling pathways. Its applications span cancer biology research, drug target screening, and mechanistic studies in developmental biology. Current research focuses on resolving its contradictory roles (oncogene vs. tumor suppressor) and exploring its diagnostic or therapeutic potential. The recombinant protein is often purified using affinity tags (e.g., His-tag) and validated by methods like SDS-PAGE and western blotting. Despite advances, further work is needed to clarify its context-dependent functions and clinical relevance.
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