| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF690 |
| Uniprot No | Q8IWY8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-284 aa |
| 活性数据 | MGSEKEQSPEPHLPEEGEGGKPWRVDDSEGSWIPPGEKEHGQESLSDELQETHPKKPWQKVTVRARELGDPIAHPRHEADEKPFICAQCGKTFNNTSNLRTHQRIHTGEKPYKCSECGKSFSRSSNRIRHERIHLEEKHYKCPKCQESFRRRSDLTTHQQDHLGKRPYRCDICGKSFSQSATLAVHHRTHLEPAPYICCECGKSFSNSSSFGVHHRTHTGERPYECTECGRTFSDISNFGAHQRTHRGEKPYRCTVCGKHFSRSSNLIRHQKTHLGEQAGKDSS |
| 分子量 | 58.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZNF690蛋白的3篇示例参考文献(注：根据现有知识模拟生成，若需真实文献请通过学术数据库检索)：
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1. **"Cloning and Expression Analysis of Human Zinc Finger Protein ZNF690 in Cancer Cell Lines"**
*作者：Zhang L. et al. (2020)*
**摘要**：本研究成功克隆了ZNF690基因，并在HEK293细胞中表达纯化了重组ZNF690蛋白。实验发现ZNF690在结肠癌细胞中表达上调，可能通过调控Wnt信号通路影响肿瘤增殖。
2. **"Functional Characterization of Recombinant ZNF690 as a Transcriptional Repressor in Stem Cell Differentiation"**
*作者：Chen Y. et al. (2018)*
**摘要**：通过构建重组ZNF690蛋白并分析其DNA结合活性，揭示了ZNF690通过结合靶基因启动子区域抑制转录，参与胚胎干细胞向神经谱系分化的调控机制。
3. **"Proteomic Screening of ZNF690-Interacting Proteins and Its Role in Viral Immunity"**
*作者：Wang J. et al. (2022)*
**摘要**：利用重组ZNF690蛋白进行免疫共沉淀-质谱分析，鉴定出多种与天然免疫应答相关的相互作用蛋白(如RIG-I)，提示ZNF690可能在抗病毒信号通路中发挥调控作用。
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**注**：ZNF690属于C2H2型锌指蛋白家族，目前公开研究较少，上述内容基于同类锌指蛋白研究模式推测，建议通过**PubMed/Google Scholar**以“ZNF690 recombinant protein”或“ZNF690 function”为关键词检索最新文献。
Zinc finger protein 690 (ZNF690) is a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family, which represents one of the largest groups of transcription regulators in humans. These proteins typically feature multiple C2H2-type zinc finger motifs that mediate sequence-specific DNA binding, enabling targeted gene regulation. ZNF690. encoded by the *ZNF690* gene on chromosome 16. is hypothesized to participate in transcriptional repression through its KRAB domain, which recruits corepressors to modulate chromatin structure and silence gene expression. While its precise biological functions remain understudied, ZNF690 is speculated to play roles in cellular processes such as differentiation, apoptosis, and immune response regulation. Emerging studies suggest potential links between ZNF690 dysregulation and diseases, including cancers and autoimmune disorders, though mechanistic insights are limited. Recombinant ZNF690 protein, produced via expression systems like *E. coli* or mammalian cells, serves as a critical tool for investigating its DNA-binding specificity, protein-protein interactions, and regulatory networks. Ongoing research aims to unravel its target genes, signaling pathways, and therapeutic relevance, positioning ZNF690 as a promising subject for both basic and applied biomedical studies.
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