关键信息
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基因名
JAM-B/CD322
- 应用
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别名
Junctional adhesion molecule 2 ;JAM-2Vascular endothelial junction-associated molecule ;VE-JAM; CD322
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P57087
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表达区间
29-238aa
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分子量
27.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
JAM-B (Junctional Adhesion Molecule B) is a member of the immunoglobulin superfamily and plays a critical role in cell adhesion and tight junction formation, particularly in endothelial and epithelial cells. Research has increasingly focused on JAM-B due to its involvement in various physiological and pathological processes, including inflammation, immune responses, and tumor metastasis. Another critical protein, CD322, is often identified as a receptor for JAM-B, facilitating intercellular communication and influencing leukocyte migration. The reconstitution of JAM-B/CD322 recombinant proteins aims to elucidate their structure-function relationships and understand their roles in cellular interactions and signaling pathways. This research holds potential implications for therapeutic strategies targeting inflammatory diseases and cancer, as modulation of JAM-B/CD322 interactions may alter disease progression or enhance tissue repair mechanisms. Overall, the study of JAM-B/CD322 recombinant proteins contributes to a greater understanding of cell adhesion mechanisms in health and disease, paving the way for novel biomedical applications.
