| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MTA2 |
| Uniprot No | O94776 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-668aa |
| 氨基酸序列 | MAANMYRVGD YVYFENSSSN PYLVRRIEEL NKTANGNVEA KVVCLFRRRD ISSSLNSLAD SNAREFEEES KQPGVSEQQR HQLKHRELFL SRQFESLPAT HIRGKCSVTL LNETDILSQY LEKEDCFFYS LVFDPVQKTL LADQGEIRVG CKYQAEIPDR LVEGESDNRN QQKMEMKVWD PDNPLTDRQI DQFLVVARAV GTFARALDCS SSIRQPSLHM SAAAASRDIT LFHAMDTLQR NGYDLAKAMS TLVPQGGPVL CRDEMEEWSA SEAMLFEEAL EKYGKDFNDI RQDFLPWKSL ASIVQFYYMW KTTDRYIQQK RLKAAEADSK LKQVYIPTYT KPNPNQIISV GSKPGMNGAG FQKGLTCESC HTTQSAQWYA WGPPNMQCRL CASCWIYWKK YGGLKTPTQL EGATRGTTEP HSRGHLSRPE AQSLSPYTTS ANRAKLLAKN RQTFLLQTTK LTRLARRMCR DLLQPRRAAR RPYAPINANA IKAECSIRLP KAAKTPLKIH PLVRLPLATI VKDLVAQAPL KPKTPRGTKT PINRNQLSQN RGLGGIMVKR AYETMAGAGV PFSANGRPLA SGIRSSSQPA AKRQKLNPAD APNPVVFVAT KDTRALRKAL THLEMRRAAR RPNLPLKVKP TLIAVRPPVP LPAPSHPAST NEPIVLED |
| 预测分子量 | kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于MTA2重组蛋白的3篇参考文献示例(内容为虚构，仅作格式参考)：
1. **文献名称**：*MTA2 Recombinant Protein Facilitates Chromatin Remodeling in Breast Cancer Cells*
**作者**：Zhang L, et al.
**摘要**：本研究通过表达纯化MTA2重组蛋白，证明其与NuRD复合物协同作用，调控乳腺癌细胞的染色质结构，增强转移相关基因的转录活性。
2. **文献名称**：*Structural and Functional Analysis of MTA2 in the Histone Deacetylase Complex*
**作者**：Kumar R, et al.
**摘要**：利用重组MTA2蛋白进行体外结合实验，揭示其通过C端结构域与HDAC1/2互作，维持复合物稳定性，并抑制抑癌基因表达。
3. **文献名称**：*Development of a High-Yield MTA2 Recombinant Protein System for Drug Screening*
**作者**：Chen H, et al.
**摘要**：优化了大肠杆菌中MTA2重组蛋白的表达条件，建立高效纯化流程，并应用于靶向MTA2的小分子抑制剂筛选，为癌症治疗提供新策略。
(注：以上文献信息为模拟生成，实际研究中请参考具体数据库如PubMed的检索结果。)
MTA2 (Metastasis-associated protein 2) is a member of the MTA protein family, initially identified for its role in cancer metastasis. It functions as a transcriptional coregulator within the nucleosome remodeling and histone deacetylation (NuRD) complex, modulating chromatin structure and gene expression. MTA2 is implicated in epigenetic regulation, particularly through its interaction with histone deacetylases (HDACs), influencing pathways critical for cell proliferation, differentiation, and metastasis. Its overexpression has been observed in various cancers, including breast, colorectal, and pancreatic cancers, correlating with tumor aggressiveness and poor prognosis.
Recombinant MTA2 protein is engineered using expression systems like *E. coli* or mammalian cells to produce purified, biologically active protein for research. This recombinant form retains functional domains, such as the SANT and GATA-binding motifs, enabling studies on its molecular interactions, post-translational modifications, and regulatory mechanisms. Researchers employ MTA2 recombinant protein to investigate its role in cancer progression, DNA repair, and resistance to therapies. It also serves as a tool for screening potential inhibitors targeting MTA2-NuRD interactions, aiming to develop anticancer therapies. Additionally, its involvement in non-cancer processes, including immune response and metabolic regulation, is an emerging area of interest. The availability of recombinant MTA2 accelerates both basic research and translational applications in oncology and epigenetics.
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