| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TMEM98 |
| Uniprot No | Q9Y2Y6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 25-226aa |
| 氨基酸序列 | LVCRQRYCRPRDLLQRYDSKPIVDLIGAMETQSEPSELELDDVVITNPHIEAILENEDWIEDASGLMSHCIAILKICHTLTEKLVAMTMGSGAKMKTSASVSDIIVVAKRISPRVDDVVKSMYPPLDPKLLDARTTALLLSVSHLVLVTRNACHLTGGLDWIDQSLSAAEEHLEVLREAALASEPDKGLPGPEGFLQEQSAI |
| 预测分子量 | 26.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于TMEM98重组蛋白的3篇参考文献的简要总结(注：以下内容为虚构示例，仅用于演示格式)：
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1. **文献名称**：*TMEM98 Recombinant Protein Expression and Characterization in E. coli*
**作者**：Zhang L, et al.
**摘要**：本研究成功在大肠杆菌中表达了TMEM98重组蛋白，优化了纯化条件并通过质谱验证其结构。实验表明该蛋白具有跨膜结构域稳定性，为后续功能研究奠定基础。
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2. **文献名称**：*Role of TMEM98 in Corneal Development: Insights from Recombinant Mutant Analysis*
**作者**：Smith J, Patel R.
**摘要**：通过表达野生型和突变型TMEM98重组蛋白，发现其与角膜胶原基质组装相关。突变体导致蛋白分泌异常，提示其与圆锥角膜发病机制的潜在关联。
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3. **文献名称**：*Structural and Functional Interaction of TMEM98 with Myosin 10*
**作者**：Wang Y, et al.
**摘要**：利用重组TMEM98蛋白进行体外结合实验，发现其与Myosin 10存在直接相互作用，揭示了其在细胞骨架调控中的新功能，并解析了关键结合位点。
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(注：如需真实文献，建议通过PubMed或Web of Science以“TMEM98 recombinant protein”为关键词检索。)
TMEM98 (Transmembrane Protein 98) is a conserved eukaryotic protein encoded by the *TMEM98* gene located on human chromosome 17q11.2. It is predicted to be a multi-pass transmembrane protein, though its precise structure and biological functions remain partially characterized. Initial studies linked TMEM98 to cellular adhesion, extracellular matrix interactions, and potential roles in developmental processes. Recent research highlights its involvement in regulating eye development, particularly in maintaining corneal transparency and lens integrity. Mutations in *TMEM98* have been associated with autosomal dominant nanophthalmos, a rare ocular disorder characterized by small eyes and vision defects, suggesting its critical role in ocular morphogenesis.
Recombinant TMEM98 protein is engineered for in vitro studies to elucidate its molecular mechanisms. Produced via heterologous expression systems (e.g., E. coli, mammalian cells), the purified protein enables investigations into its interactions with extracellular matrix components like collagen, as well as its putative signaling pathways. Researchers utilize recombinant TMEM98 to study its impact on cell proliferation, migration, and tissue homeostasis, particularly in ocular and epithelial tissues. Additionally, it serves as an antigen for antibody development to explore its tissue distribution and disease-related expression changes. Despite progress, TMEM98's full functional repertoire, including potential roles in cancer or metabolic regulation, remains under investigation. Its recombinant form is a vital tool for unraveling its contributions to both physiological and pathological processes.
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