| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IFNGR1; IFNGR; IMD27A; IMD27B |
| Entrez GeneID | 3459 |
| clone | 5H1C9 |
| WB Predicted band size | 54.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD119 (AA: extra 18-245) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于CD119(IFNγR1)抗体的代表性文献摘要：
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1. **文献名称**: *"Interferon-γ receptor signaling in innate immunity and host defense"*
**作者**: Bach EA 等
**摘要**: 该综述详细探讨了IFNγR1(CD119)在先天免疫中的核心作用，包括其信号传导机制及与感染性疾病(如分枝杆菌感染)的关联。作者强调了针对CD119的抗体在阻断IFN-γ通路研究中的应用价值。
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2. **文献名称**: *"Genetic deficiency of interferon gamma receptor reveals its critical role in mycobacterial immunity"*
**作者**: Jouanguy E 等
**摘要**: 本研究通过基因分析揭示了IFNγR1(CD119)缺陷与遗传性严重分枝杆菌易感性之间的直接关联。文中利用抗CD119抗体验证受体表达缺失，为原发性免疫缺陷的分子机制提供了关键证据。
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3. **文献名称**: *"Targeting IFNγ receptor in autoimmune diseases: Insights from antibody blockade"*
**作者**: Gough SC 等
**摘要**: 研究团队通过抗CD119抗体抑制IFN-γ信号通路，验证其在实验性自身免疫性疾病(如类风湿性关节炎)中的治疗潜力，表明靶向该受体可减轻炎症反应和组织损伤。
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**备注**：以上文献为示例性内容，实际引用时建议通过PubMed或Google Scholar以“CD119 antibody”或“IFNγR1”为关键词检索最新研究。若需具体文献DOI或发表年份，可进一步补充信息。
CD119 antibody targets the CD119 antigen, also known as the interferon gamma receptor 1 (IFNGR1), a critical component of the immune system. IFNGR1 is a cell surface receptor that binds to interferon-gamma (IFN-γ), a cytokine pivotal in mediating innate and adaptive immunity. Structurally, it is a transmembrane protein that forms a heterodimeric complex with IFNGR2 to activate downstream signaling via the JAK-STAT pathway, triggering antimicrobial, antiviral, and antitumor responses.
CD119 is expressed on immune cells (e.g., macrophages, T cells) and non-immune cells, playing roles in pathogen clearance, antigen presentation, and inflammation regulation. Mutations in the IFNGR1 gene are linked to Mendelian Susceptibility to Mycobacterial Diseases (MSMD), a rare immunodeficiency disorder characterized by severe infections with weakly virulent mycobacteria.
CD119 antibodies are widely used in research to study IFN-γ signaling, immune cell activation, and disease mechanisms. They are also employed in diagnostics (e.g., flow cytometry, immunohistochemistry) to quantify receptor expression in immune disorders or cancers. Therapeutic applications are emerging, with some antibodies explored as antagonists to modulate hyperinflammatory responses or as agonists to enhance IFN-γ pathway activity in immunodeficiencies. Their specificity makes them valuable tools for dissecting IFN-γ-related pathologies and developing targeted therapies.
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