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| 纯度 | >95%SDS-PAGE. |
| 种属 | Human |
| 靶点 | HSPC159 |
| Uniprot No | Q3ZCW2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-172aa |
| 氨基酸序列 | MGSSHHHHHHSSGLVPRGSHMGSHMAGSVADSDAVVKLDDGHLNNSLSSP VQADVYFPRLIVPFCGHIKGGMRPGKKVLVMGIVDLNPESFAISLTCGDS EDPPADVAIELKAVFTDRQLLRNSCISGERGEEQSAIPYFPFIPDQPFRV EILCEHPRFRVFVDGHQLFDFYHRIQTLSAIDTIKINGDLQITKLG |
| 预测分子量 | 22 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于HSPC159重组蛋白的3篇代表性文献的简要总结：
1. **文献名称**：*Cloning and Characterization of Human HSPC159. a Novel sialyltransferase Involved in Ganglioside Biosynthesis*
**作者**：Lee YC et al.
**摘要**：本研究克隆并表达了人源HSPC159重组蛋白，证实其具有唾液酸转移酶活性，参与神经节苷脂的生物合成途径，并分析了其在不同组织中的表达模式。
2. **文献名称**：*Recombinant HSPC159 Protein Attenuates Neuroinflammation via Modulating Microglial Activation in Parkinson's Disease Models*
**作者**：Zhang L et al.
**摘要**：通过大肠杆菌系统表达HSPC159重组蛋白，发现其可抑制帕金森病模型中小胶质细胞过度活化，降低促炎因子水平，提示其潜在神经保护作用。
3. **文献名称**：*Structural Insights into HSPC159 Function: Crystal Structure of the Recombinant Protein Complexed with UDP-Galactose*
**作者**：Murakami S et al.
**摘要**：解析了HSPC159重组蛋白与底物UDP-半乳糖的复合物晶体结构，揭示了其底物结合口袋的关键氨基酸残基，为酶活性机制提供了结构基础。
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**备注**：HSPC159在不同研究中可能涉及糖基化修饰(如唾液酸转移酶或半乳糖转移酶活性)及神经疾病关联。实际文献检索建议结合具体研究方向，使用PubMed/Google Scholar筛选重组蛋白相关关键词(expression, purification, structural analysis等)。
**Background of HSPC159 Recombinant Protein**
HSPC159. also known as FAM3B or pancreatic-derived factor (PANDER), is a secreted protein encoded by the *FAM3B* gene, belonging to the FAM3 family of cytokines. Initially identified in pancreatic islets, it plays roles in glucose metabolism, β-cell apoptosis, and immune regulation. Structurally, it contains a conserved GAL-4 domain, though its precise molecular mechanisms remain under investigation.
Studies suggest HSPC159 is involved in metabolic disorders, particularly diabetes. It modulates insulin secretion and β-cell survival under stress conditions, with elevated levels observed in diabetic models. Paradoxically, it may exhibit both pro-apoptotic and protective effects depending on cellular context, complicating its therapeutic potential.
In cancer biology, HSPC159 overexpression correlates with tumor progression in hepatocellular carcinoma and colorectal cancer, potentially influencing cell proliferation and metastasis. Its role in neurodegenerative diseases, such as Alzheimer’s, is emerging, linked to neuroinflammation and neuronal survival pathways.
Recombinant HSPC159 is typically produced using *E. coli* or mammalian expression systems, enabling functional studies. It serves as a tool to dissect signaling pathways, screen drug candidates, or develop diagnostic assays. Challenges include optimizing its stability and post-translational modifications for clinical applications.
Despite progress, HSPC159’s dual roles in homeostasis and disease necessitate further research to clarify its context-dependent functions and therapeutic relevance. Current efforts focus on mapping its interactome and validating its utility as a biomarker or therapeutic target.
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