| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | C53; IC53; LZAP; HSF-27; MST016; PP1553; OK/SW-cl.114 |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CDK5RAP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是模拟生成的关于CDK5RAP3抗体的参考文献示例，供参考格式和内容。实际文献需通过学术数据库检索获取：
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1. **文献名称**：*CDK5RAP3 regulates hepatocellular carcinoma progression via Wnt/β-catenin signaling*
**作者**：Li, X., et al.
**摘要**：本研究利用CDK5RAP3特异性抗体，通过免疫组化和Western blot技术，发现CDK5RAP3在肝癌组织中高表达，并激活Wnt/β-catenin通路，促进肿瘤侵袭和转移。
2. **文献名称**：*A novel role of CDK5RAP3 in neuronal differentiation*
**作者**：Wang, Y., et al.
**摘要**：通过免疫荧光和共聚焦显微镜结合CDK5RAP3抗体，作者发现CDK5RAP3在神经元分化过程中调控微管稳定性，影响神经突触的形成和功能。
3. **文献名称**：*CDK5RAP3 interacts with p53 and modulates DNA damage response*
**作者**：Chen, H., et al.
**摘要**：利用免疫共沉淀(Co-IP)和CDK5RAP3抗体，研究发现CDK5RAP3与p53蛋白直接结合，增强DNA损伤修复能力，抑制肿瘤细胞凋亡。
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**备注**：以上为模拟示例，具体文献需通过PubMed、Google Scholar等平台以关键词“CDK5RAP3 antibody”或“CDK5RAP3 function”检索获取。
CDK5RAP3 (Cyclin-Dependent Kinase 5 Regulatory Subunit Associated Protein 3) is a multifunctional protein implicated in diverse cellular processes, including cell cycle regulation, signal transduction, and stress response. Initially identified as a binding partner of CDK5R1. it interacts with components of the Wnt/β-catenin and Hedgehog pathways, influencing cell proliferation and differentiation. CDK5RAP3 also plays roles in maintaining genomic stability and modulating the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Dysregulation of CDK5RAP3 has been linked to cancers, neurodegenerative disorders, and metabolic diseases, highlighting its potential as a therapeutic target or biomarker.
Antibodies targeting CDK5RAP3 are essential tools for studying its expression, localization, and molecular interactions. These antibodies enable techniques like Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to explore its tissue-specific distribution, subcellular dynamics, and functional networks. Given structural similarities among CDK5RAP family members, rigorous validation (e.g., knockout controls) is critical to ensure antibody specificity. Reliable CDK5RAP3 antibodies advance research into its pathological mechanisms, offering insights for drug development and diagnostic strategies.
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