| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | PANE1; CENP-M; C22orf18; bK250D10.2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CENPM抗体的3篇文献摘要概括(基于公开研究整理，部分为模拟示例)：
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1. **文献名称**：*CENPM promotes hepatocellular carcinoma progression through regulating Wnt/β-catenin signaling*
**作者**：Li Y, et al.
**摘要**：研究利用CENPM抗体进行免疫组化和Western blot分析，发现CENPM在肝癌组织中高表达，并通过激活Wnt信号通路促进肿瘤侵袭和转移，提示其作为潜在治疗靶点。
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2. **文献名称**：*CENPM as a novel biomarker for triple-negative breast cancer prognosis*
**作者**：Wang X, et al.
**摘要**：通过CENPM抗体检测乳腺癌组织样本，研究发现CENPM高表达与三阴性乳腺癌患者的不良预后相关，机制涉及细胞周期调控异常和基因组不稳定性。
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3. **文献名称**：*Functional analysis of CENPM in mitotic fidelity and chromosomal stability*
**作者**：Smith J, et al.
**摘要**：利用CENPM特异性抗体进行免疫荧光染色，揭示CENPM在维持着丝粒功能和染色体正确分离中的关键作用，其缺失导致有丝分裂错误和细胞凋亡增加。
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**备注**：以上文献为示例性质，实际研究请通过PubMed或Google Scholar以关键词“CENPM antibody”或“CENPM function”检索最新论文。
The CENPM (Centromere Protein M) antibody is a crucial tool in studying the role of CENPM, a key component of the centromere/kinetochore complex essential for proper chromosome segregation during cell division. CENPM is part of the constitutive centromere-associated network (CCAN), which stabilizes kinetochore-microtubule interactions and ensures accurate mitotic checkpoint signaling. It plays a vital role in maintaining genomic stability by regulating the assembly and function of the kinetochore, particularly during the G2/M phase transition.
CENPM antibodies are widely used in research to investigate its expression, localization, and interactions in both normal and pathological contexts. In cancer biology, CENPM overexpression has been linked to tumorigenesis, as dysregulated chromosome segregation can drive genomic instability and aneuploidy. Studies using CENPM antibodies have revealed its upregulation in various cancers, including breast, liver, and lung cancers, correlating with poor prognosis and chemoresistance. These antibodies enable techniques like Western blotting, immunofluorescence, and immunohistochemistry to visualize CENPM's spatial distribution in cells and tissues.
Additionally, CENPM antibodies contribute to understanding congenital disorders related to centromere dysfunction. Their application in functional assays (e.g., ChIP-seq) helps map centromeric regions and dissect epigenetic regulation mechanisms. As research advances, CENPM antibodies remain pivotal in exploring cell cycle control, cancer biomarkers, and therapeutic targets for precision oncology.
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