| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | BM039; CENP-N; ICEN32; C16orf60 |
| WB Predicted band size | 40 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CENPN抗体的3篇虚构参考文献示例(仅供格式参考)：
1. **标题**: *CENPN作为癌症基因组不稳定性的关键调控因子*
**作者**: Zhang, L. et al.
**摘要**: 研究揭示CENPN在有丝分裂中维持着丝粒完整性，其表达缺失导致染色体错误分离，与多种实体瘤的基因组不稳定性显著相关。
2. **标题**: *CENPN抗体在结直肠癌早期诊断中的临床应用*
**作者**: Smith, J.R. & Wang, H.
**摘要**: 开发高特异性CENPN单克隆抗体，证实其在结直肠癌患者组织中过表达，可作为血清生物标志物用于早期筛查(灵敏度92%，特异性88%)。
3. **标题**: *CENPN与BRCA1互作调控DNA损伤修复的分子机制*
**作者**: Tanaka, K. et al.
**摘要**: 通过免疫共沉淀(Co-IP)实验证实CENPN与BRCA1蛋白存在直接结合，共同参与同源重组修复通路，突变体导致乳腺癌细胞放疗抗性增强。
注：以上为模拟内容，实际文献需通过PubMed/Google Scholar检索关键词“CENPN antibody”或“CENPN function”获取。
The CENPN antibody targets Centromere Protein N (CENPN), a key component of the constitutive centromere-associated network (CCAN) essential for proper chromosome segregation during mitosis and meiosis. CENPN localizes to centromeres and interacts with other CCAN proteins, such as CENP-A, CENP-C, and CENP-T, to stabilize kinetochore-microtubule attachments and ensure accurate chromosome alignment. Dysregulation of CENPN is linked to genomic instability, aneuploidy, and cancer progression.
CENPN antibodies are widely used in research to study centromere biology, mitotic mechanisms, and chromosomal disorders. They enable the detection of CENPN via techniques like immunofluorescence, Western blotting, and chromatin immunoprecipitation (ChIP). These antibodies help investigate CENPN's role in cell cycle regulation, its interaction partners, and its overexpression in malignancies such as breast, liver, and colorectal cancers. Validated CENPN antibodies are critical for distinguishing between normal and aberrant centromere function in diseases or experimental models. Commercial CENPN antibodies are typically tested for specificity using knockout cell lines or siRNA-mediated knockdown. Researchers also employ them to explore potential therapeutic strategies targeting centromere dysfunction in cancer or developmental disorders. As a biomarker, CENPN expression levels may correlate with patient prognosis, making its antibody a tool for both basic research and clinical applications.
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