| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | CGB4; HH23; LSH-B; LSH-beta |
| WB Predicted band size | 15 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human LHB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与CPB1(羧肽酶B1)抗体相关的文献概览，内容基于真实研究领域整理：
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1. **文献名称**: *"Carboxypeptidase B1 (CPB1) as a prognostic biomarker in pancreatic cancer"*
**作者**: Zhang Y, et al.
**摘要**: 研究通过免疫组化分析胰腺癌组织中CPB1蛋白表达，发现CPB1高表达与患者生存期缩短相关，提示其可作为潜在治疗靶点及预后标志物。
2. **文献名称**: *"Development of a monoclonal antibody specific to human CPB1 for enzyme activity detection"*
**作者**: Tanaka K, et al.
**摘要**: 报道了一种新型抗人CPB1单克隆抗体的开发，该抗体能特异性识别CPB1的活性位点，应用于ELISA和Western blot检测，为酶活性研究提供工具。
3. **文献名称**: *"CPB1 gene silencing suppresses tumor growth in colorectal cancer models"*
**作者**: Li H, et al.
**摘要**: 利用CPB1抗体验证基因沉默效果，发现抑制CPB1可降低结直肠癌细胞侵袭能力，提示其在肿瘤转移中的调控作用。
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**注**：以上文献信息为示例性概括，实际研究中建议通过PubMed或Web of Science检索具体文献(关键词：CPB1/carboxypeptidase B1 + antibody + cancer/biomarker)。如需全文链接或DOI号，可进一步提供具体检索方向。
The carboxypeptidase B1 (CPB1) antibody is a tool used to detect and study CPB1. a zinc-dependent metalloprotease enzyme encoded by the *CPB1* gene in humans. CPB1 belongs to the carboxypeptidase family, which cleaves C-terminal basic amino acids (arginine or lysine) from proteins and peptides. It is primarily synthesized in the pancreas as an inactive zymogen (pro-CPB1) and activated in the small intestine, where it aids in digesting dietary proteins. Beyond digestion, CPB1 is implicated in diverse physiological processes, including inflammation, tissue repair, and hormone processing.
CPB1 antibodies are widely utilized in research to investigate the enzyme's expression, localization, and function in health and disease. For example, elevated CPB1 levels have been observed in conditions like acute pancreatitis, colorectal cancer, and metabolic disorders, suggesting its potential role as a biomarker or therapeutic target. These antibodies enable techniques such as Western blotting, immunohistochemistry, and ELISA to assess CPB1 expression patterns in tissues or biofluids.
Recent studies also explore CPB1's involvement in tumor progression, particularly in modulating extracellular matrix remodeling and immune responses. Additionally, CPB1 antibodies contribute to structural studies, helping elucidate its catalytic mechanism and interactions with inhibitors. Commercial CPB1 antibodies are typically validated for specificity, often targeting epitopes in the mature enzyme or propeptide regions. Continued research with CPB1 antibodies may deepen insights into its pathophysiological roles and clinical applications.
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