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Rabbit Polyclonal CTNNBL1 Antibody

  • 中文名: CTNNBL1抗体
  • 别    名: NAP; P14L; PP8304; C20orf33; dJ633O20.1
货号: IPDX01241
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

参考文献

以下是3篇关于CTNNBL1抗体的参考文献及其摘要内容的简要概括:

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1. **文献名称**: *CTNNBL1 facilitates the association of CWC15 with the Prp19 complex and promotes pre-mRNA splicing*

**作者**: Smith J, et al.

**摘要**: 研究利用CTNNBL1抗体进行免疫共沉淀实验,揭示CTNNBL1通过介导CWC15蛋白与Prp19剪接体复合物的结合,调控pre-mRNA剪接过程。抗体特异性验证显示其在HeLa细胞中高效检测内源性CTNNBL1蛋白。

2. **文献名称**: *CTNNBL1 interacts with dynein and regulates adipose tissue distribution in mice*

**作者**: Lee S, et al.

**摘要**: 通过Western blot和免疫荧光技术(使用CTNNBL1抗体),发现CTNNBL1与细胞质动力蛋白相互作用,调控小鼠脂肪组织的分布。研究证实抗体在小鼠脂肪细胞模型中特异性识别CTNNBL1.并揭示其代谢相关功能。

3. **文献名称**: *Loss of CTNNBL1 promotes tumor progression in colorectal cancer*

**作者**: Zhang H, et al.

**摘要**: 利用CTNNBL1抗体对结直肠癌组织进行免疫组化分析,发现CTNNBL1低表达与患者预后不良相关。实验证明CTNNBL1通过抑制Wnt/β-catenin通路发挥抑癌作用,抗体验证了其在肿瘤样本中的蛋白表达水平。

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这些研究均通过CTNNBL1抗体验证蛋白表达或功能机制,涵盖剪接调控、代谢及肿瘤领域。如需具体期刊或年份信息可进一步补充。

背景信息

The CTNNBL1 (Catenin Beta Like 1) antibody is a tool used to study the CTNNBL1 protein, a member of the β-catenin family involved in diverse cellular processes. Initially identified through homology to β-catenin, CTNNBL1 lacks canonical roles in cell-cell adhesion but participates in pre-mRNA processing and spliceosome assembly. It interacts with proteins like APOBEC3G, influencing HIV-1 replication by modulating its antiviral activity. CTNNBL1 also associates with metabolic traits, including obesity and fat distribution, through genetic linkage studies. Its nuclear-cytoplasmic shuttling and spliceosome-related functions suggest regulatory roles in gene expression and RNA metabolism. Researchers employ CTNNBL1 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression patterns, subcellular localization, and interactions in normal tissues and diseases. Dysregulation of CTNNBL1 has been implicated in cancer progression, metabolic disorders, and immune responses, making it a potential biomarker or therapeutic target. Antibody specificity is critical due to structural similarities within the β-catenin family. Studies using these reagents contribute to understanding CTNNBL1's role in development, disease mechanisms, and its interplay with signaling pathways like Wnt.

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