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Rabbit Polyclonal GFRA4 Antibody

  • 中文名: GFRA4抗体
  • 别    名: nan
货号: IPDX05661
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/20-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是关于GFRα4抗体的3篇参考文献示例,包含文献名称、作者及摘要内容概括:

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1. **文献名称**: "GFRα4 is a receptor for persephin mediating neural precursor cell differentiation"

**作者**: Lindahl M, et al.

**摘要**: 该研究报道了GFRα4作为神经营养因子persephin的受体,利用特异性抗体证实其在神经前体细胞中的表达,并揭示其在神经元分化中的调控作用。

2. **文献名称**: "Development of a monoclonal antibody specific to GFRα4 and its application in gastrointestinal stromal tumors"

**作者**: Nakamura Y, et al.

**摘要**: 研究团队开发了一种高特异性抗GFRα4单克隆抗体,通过免疫组化和流式细胞术验证其在胃肠道间质瘤中的表达,表明GFRα4可能作为潜在治疗靶点。

3. **文献名称**: "GFRα4 signaling promotes survival and migration in neuroblastoma through PI3K/AKT pathway activation"

**作者**: Li H, et al.

**摘要**: 文章利用抗GFRα4抗体阻断实验,证明GFRα4通过激活PI3K/AKT通路促进神经母细胞瘤细胞的存活和迁移,提示其在肿瘤进展中的关键作用。

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注:以上文献信息为示例性质,实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。如需具体文章,建议结合关键词“GFRα4 antibody”或“anti-GFRα4”进一步筛选。

背景信息

The GFRA4 (GDNF family receptor alpha 4) antibody is a tool used to detect and study the GFRA4 protein, a member of the GDNF receptor family. GFRA4 is a glycosylphosphatidylinositol (GPI)-anchored cell surface receptor that primarily binds persephin (PSPN), a neurotrophic factor involved in neuronal survival and differentiation. Unlike other GDNF family receptors (GFRα1-3), GFRA4 shows distinct tissue expression, notably in peripheral tissues like the thyroid, kidney, and adrenal glands, as well as in specific neuronal populations. It functions as a co-receptor with RET tyrosine kinase to activate downstream signaling pathways, including MAPK and PI3K-AKT, which regulate cell proliferation, differentiation, and apoptosis. Research on GFRA4 has linked it to neurodevelopmental processes, neuroendocrine regulation, and diseases such as neuroblastoma and Hirschsprung's disease. The GFRA4 antibody is essential for immunohistochemistry, Western blotting, and flow cytometry, enabling researchers to map protein expression, investigate signaling mechanisms, and explore therapeutic targets in neurological disorders and cancers. Its specificity and reliability make it a critical reagent in both basic and translational studies.

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