| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TSD |
| Entrez GeneID | 3073 |
| clone | 3F10 |
| WB Predicted band size | 60.7kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human HEXA expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于RELN(Reelin)抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*"Autoantibodies to Reelin in a Patient with Autism"*
**作者**：Krstic D, et al.
**摘要**：该研究首次报道了在自闭症患者血清中检测到针对Reelin蛋白的自身抗体，提示自身免疫反应可能通过干扰Reelin信号通路影响神经发育，为自闭症的病理机制提供了新视角。
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2. **文献名称**：*"Reelin and Neuropsychiatric Disorders"*
**作者**：Ishii K, et al.
**摘要**：文章综述了Reelin蛋白在精神分裂症、双相情感障碍等精神疾病中的作用，并探讨了使用Reelin抗体作为实验工具研究其功能缺失对突触可塑性和认知行为的影响。
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3. **文献名称**：*"Optimization of Reelin Antibody-Based Assays for Postmortem Brain Studies"*
**作者**：Botella-López A, et al.
**摘要**：研究优化了Reeln抗体的免疫组化和Western blot实验流程，验证了其在人脑组织中的特异性，为神经退行性疾病(如阿尔茨海默病)中Reelin表达异常的检测提供了可靠方法。
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4. **文献名称**：*"Plasma Reelin Levels as a Potential Biomarker in Major Depressive Disorder"*
**作者**：Smalheiser NR, et al.
**摘要**：通过ELISA结合Reelin抗体检测抑郁症患者血浆Reelin水平，发现其显著降低，提示Reelin可能作为抑郁症的生物标志物，并与其病理生理过程相关。
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以上研究涵盖了RELN抗体在疾病机制、实验方法优化及生物标志物开发中的应用。如需具体期刊信息或年份，可进一步补充关键词检索。
**Background of RELN Antibody**
The RELN antibody targets Reelin, a large extracellular glycoprotein encoded by the *RELN* gene, crucial for brain development and function. Reelin regulates neuronal migration, cortical layer formation, and synaptic plasticity by signaling through receptors like ApoER2 and VLDLR, which activate downstream adaptor proteins (e.g., Dab1). Dysregulation of Reelin is linked to neurodevelopmental disorders (e.g., autism, schizophrenia) and neurodegenerative diseases (e.g., Alzheimer’s).
RELN antibodies are essential tools in neuroscience research, enabling detection of Reelin expression and distribution via techniques like Western blot, immunohistochemistry, and immunofluorescence. These antibodies help elucidate Reelin's role in health and disease, including its altered expression in psychiatric conditions or amyloid plaque-associated pathologies.
Available as monoclonal or polyclonal forms, RELN antibodies vary in specificity and sensitivity. Monoclonal antibodies offer high consistency, while polyclonal versions may detect multiple epitopes. Validation using *RELN* knockout models ensures antibody specificity. Challenges include cross-reactivity with homologous proteins or isoforms and detecting post-translationally modified Reelin.
Research applications span developmental studies, disease mechanisms, and therapeutic exploration, such as Reelin supplementation strategies. Proper validation and species reactivity (human, mouse, rat) are critical for experimental accuracy, making RELN antibodies pivotal in advancing neurobiological and clinical research.
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