| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | VIIAL; COX7AL; COX7AL1; COXVIIAL; COXVIIa-L |
| WB Predicted band size | 9 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human COX7A2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于COX7A2抗体的参考文献示例(注：以下内容为示例性概括，非真实文献)：
1. **文献名称**：*COX7A2 regulates mitochondrial function and promotes tumor progression in colorectal cancer*
**作者**：Chen et al.
**摘要**：通过COX7A2抗体检测发现，其在结直肠癌组织中表达显著下调，与线粒体呼吸活性降低相关，提示COX7A2可能通过调控细胞能量代谢影响肿瘤进展。
2. **文献名称**：*Tissue-specific expression of COX7A2 isoforms in mammalian skeletal muscle*
**作者**：Smith et al.
**摘要**：利用COX7A2抗体进行免疫印迹和免疫荧光实验，揭示COX7A2在不同肌肉纤维类型中的差异表达，提示其与运动适应性代谢调控相关。
3. **文献名称**：*COX7A2 deficiency exacerbates cardiac hypertrophy via mitochondrial dysfunction*
**作者**：Wang et al.
**摘要**：研究通过COX7A2抗体敲除模型，发现COX7A2缺失导致心肌细胞线粒体复合物IV活性下降，加剧心脏肥大和心力衰竭。
4. **文献名称**：*COX7A2 as a biomarker for early detection of Parkinson’s disease*
**作者**：Garcia-Ruiz et al.
**摘要**：采用COX7A2抗体分析患者脑脊液样本，发现其表达水平与帕金森病早期病理相关，或可作为潜在诊断标志物。
(注：以上文献为模拟示例，实际引用需查询具体数据库如PubMed、Web of Science等。)
The COX7A2 antibody is a crucial tool for studying the cytochrome c oxidase (COX) complex, a key component of the mitochondrial electron transport chain (ETC) involved in cellular energy production. COX, or Complex IV, catalyzes the final step of oxidative phosphorylation, transferring electrons to oxygen to form water while driving ATP synthesis. The COX7A2 protein is one of several nuclear-encoded subunits of Complex IV, specifically part of the catalytic core. It exists in two tissue-specific isoforms: COX7A1 (ubiquitous) and COX7A2. which is predominantly expressed in skeletal muscle and heart, reflecting its role in high-energy-demand tissues.
Antibodies targeting COX7A2 enable researchers to investigate its expression, localization, and regulation in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in diseases linked to mitochondrial dysfunction, such as metabolic disorders, neurodegenerative conditions, and cancer. For instance, altered COX7A2 expression has been observed in mitochondrial myopathies and tumors, where metabolic reprogramming is a hallmark. These antibodies also aid in exploring tissue-specific COX assembly mechanisms and responses to stressors like hypoxia or exercise. Validated COX7A2 antibodies are essential for ensuring specificity, given the high homology among COX subunits. Their application advances understanding of mitochondrial biology, disease mechanisms, and potential therapeutic targets.
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