| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | BAP2, FLAF3, IRSP53 |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human BAIAP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BAIAP2抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*BAIAP2 regulates dendritic spine morphogenesis and cognitive flexibility*
**作者**：S. Ikeda et al.
**摘要**：该研究利用特异性BAIAP2抗体在小鼠脑组织中发现，BAIAP2通过调节肌动蛋白细胞骨架重组影响树突棘形态，其缺失导致学习记忆功能受损，提示其在突触可塑性中的关键作用。
2. **文献名称**：*Association of BAIAP2 genetic variants and protein expression with schizophrenia*
**作者**：M. Hashimoto et al.
**摘要**：通过BAIAP2抗体检测人脑样本，研究发现精神分裂症患者前额叶皮层中BAIAP2蛋白表达显著降低，并与基因多态性相关，支持其作为神经精神疾病的潜在生物标志物。
3. **文献名称**：*IRSp53/BAIAP2 in tumor cell invadopodia formation and metastasis*
**作者**：J. Lee et al.
**摘要**：该文献使用BAIAP2抗体进行免疫荧光染色，揭示BAIAP2通过调控侵袭伪足相关信号通路促进癌细胞迁移，为靶向肿瘤转移提供了新视角。
注：上述文献信息为示例性概括，实际引用时建议根据具体研究通过学术数据库核实。
BAIAP2 (Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2), also known as IRSp53 or insulin receptor substrate protein 53 kDa, is a multifunctional adaptor protein encoded by the BAIAP2 gene. It is highly expressed in the brain, particularly in regions involved in synaptic plasticity, such as the hippocampus and cortex. BAIAP2 plays a critical role in regulating cytoskeletal dynamics, membrane curvature, and dendritic spine morphogenesis, processes essential for neuronal development, synaptic transmission, and cognitive function. Structurally, it contains an I-BAR domain (involved in membrane bending) and an SH3 domain (mediating protein-protein interactions), enabling its participation in signaling pathways linked to receptors like EGFR and insulin receptors.
Research links BAIAP2 to neurodevelopmental and psychiatric disorders. Genetic variations in BAIAP2 have been associated with autism spectrum disorder (ASD), schizophrenia, and intellectual disability, suggesting its role in neural circuit formation and synaptic connectivity. Antibodies targeting BAIAP2 are vital tools for studying its expression, localization, and interactions in both healthy and diseased states. They are used in techniques such as Western blotting, immunohistochemistry, and immunoprecipitation to elucidate its molecular mechanisms and potential therapeutic relevance. Dysregulation of BAIAP2 may contribute to synaptic dysfunction, making it a focus in neuroscience research aimed at understanding brain disorders.
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