| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HK2, HCK1, PCN1, ATFB7, HPCN1, KV1.5 |
| WB Predicted band size | 67 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human KCNA5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与KCNA5抗体相关的参考文献示例(注：内容为模拟概括，实际文献需通过数据库核实)：
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1. **文献名称**: "Autoantibodies against KCNA5 in Scleroderma-associated Pulmonary Hypertension"
**作者**: Smith JL, et al.
**摘要**: 研究报道硬皮病相关肺动脉高压患者血清中存在抗KCNA5通道的自身抗体，这些抗体可能通过抑制钾离子流导致血管收缩，为疾病机制提供新见解。
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2. **文献名称**: "KCNA5 Antibody Localization and Atrial Fibrillation Pathology"
**作者**: Chen H, et al.
**摘要**: 利用KCNA5特异性抗体进行免疫组化分析，发现房颤患者心房组织中KCNA5蛋白表达显著下调，提示其与心律失常的电生理异常相关。
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3. **文献名称**: "Validation of a Novel KCNA5 Antibody for Western Blot and Immunofluorescence"
**作者**: Kumar R, et al.
**摘要**: 研究验证了一种高特异性KCNA5抗体的应用，证实其在Western blot和细胞免疫荧光中能准确识别重组及内源性KCNA5蛋白，为通道功能研究提供可靠工具。
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**建议**：通过PubMed或Google Scholar搜索关键词“KCNA5 antibody”、“KCNA5 autoantibody”或“KCNA5 potassium channel”可获取最新文献。
The KCNA5 antibody targets the Kv1.5 protein, encoded by the KCNA5 gene, which belongs to the voltage-gated potassium channel family. Kv1.5 is primarily expressed in cardiac atrial myocytes, where it mediates the ultra-rapid delayed rectifier potassium current (IKur), a key regulator of atrial action potential repolarization. This channel plays a critical role in maintaining normal heart rhythm, and mutations or dysregulation of KCNA5 are linked to atrial fibrillation (AF) and other cardiac arrhythmias. KCNA5 antibodies are widely used in research to study channel expression, localization, and function in both physiological and pathological contexts.
In autoimmune contexts, anti-KCNA5 autoantibodies have been detected in patients with certain connective tissue diseases, such as systemic sclerosis or lupus, and are associated with acquired atrial arrhythmias. These autoantibodies may disrupt channel activity, contributing to electrical remodeling and AF pathogenesis.
As a research tool, KCNA5 antibodies are applied in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate channel distribution in tissues or assess protein levels in disease models. They also aid in drug discovery, particularly in screening compounds targeting IKur for antiarrhythmic therapies. However, commercial KCNA5 antibodies vary in specificity, requiring careful validation to ensure accurate detection. Overall, KCNA5 antibodies serve as essential probes for unraveling the channel's role in cardiac electrophysiology and its implications in arrhythmogenic disorders.
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