| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | EST201864 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ABCF3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及ABCF3抗体的文献摘要信息，供参考：
1. **文献名称**: *ABCF3 regulates dsDNA-induced immune responses in human keratinocytes*
**作者**: Smith J, et al.
**摘要**: 本研究利用ABCF3特异性抗体，通过免疫沉淀和Western blot技术，揭示ABCF3在皮肤角质细胞中通过调控RIG-I信号通路参与抗病毒免疫反应，其表达水平与I型干扰素产生相关。
2. **文献名称**: *ABCF3 overexpression correlates with poor prognosis in colorectal cancer*
**作者**: Chen L, et al.
**摘要**: 通过免疫组化分析结直肠癌组织样本，发现ABCF3蛋白(使用兔源单克隆抗体检测)在肿瘤组织中显著高表达，且与患者总生存期缩短和化疗耐药性相关，提示其作为潜在预后标志物的价值。
3. **文献名称**: *Characterization of ABCF3 antibody specificity in ATP-binding cassette transporter studies*
**作者**: Müller R, et al.
**摘要**: 报道了一种新型ABCF3多克隆抗体的开发与验证，通过siRNA敲低和质谱分析证实其特异性，并证明ABCF3在细胞质中参与核糖体相关ATP酶活性调控，为转运蛋白功能研究提供工具。
注：上述文献为虚拟示例，实际研究中建议通过PubMed或Web of Science检索最新文献，重点关注抗体应用场景(如疾病模型、分子机制)及验证方法(如KO验证、功能实验)。
**Background of ABCF3 Antibody**
The ABCF3 antibody targets the ATP-binding cassette subfamily F member 3 (ABCF3), a protein belonging to the ATP-binding cassette (ABC) transporter superfamily. Unlike many ABC transporters involved in substrate translocation across membranes, ABCF members, including ABCF3. lack transmembrane domains and are primarily associated with regulatory roles in translation, ribosome function, and cellular stress responses. ABCF3 is ubiquitously expressed, with elevated levels observed in certain tissues like the liver and testis, and has been implicated in processes such as cell proliferation, drug resistance, and cancer progression.
Studies suggest ABCF3 may interact with ribosomes or translation factors, potentially modulating protein synthesis under stress conditions. Its dysregulation has been linked to cancers, including hepatocellular carcinoma and glioblastoma, where overexpression correlates with poor prognosis. ABCF3 antibodies are critical tools for detecting protein expression, localization, and function in research. They are utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore ABCF3's role in disease mechanisms or therapeutic resistance. Current research focuses on clarifying its molecular interactions and validating its potential as a diagnostic marker or therapeutic target in oncology.
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