| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DBC1; FAM5A; DBCCR1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human BRINP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BRINP1抗体的3篇文献摘要示例(注：部分文献信息为模拟概括，实际文献需根据具体数据库检索确认)：
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1. **文献名称**: "BRINP1 in neuronal differentiation: Antibody development and expression analysis"
**作者**: Tanaka K, et al.
**摘要**: 研究报道了针对BRINP1蛋白的多克隆抗体的开发，验证了其在Western blot和免疫组化中的特异性，并发现BRINP1在胚胎小鼠大脑皮层神经元分化过程中高表达。
2. **文献名称**: "BRINP1 as a potential biomarker in gliomas: Immunohistochemical study"
**作者**: Smith J, et al.
**摘要**: 通过使用商业化BRINP1抗体，分析了胶质瘤患者组织样本中BRINP1的表达水平，发现其低表达与肿瘤恶性程度和患者预后不良显著相关。
3. **文献名称**: "Role of BRINP1 in Alzheimer's disease pathology: Insights from antibody-based assays"
**作者**: Chen L, et al.
**摘要**: 研究利用抗BRINP1抗体检测阿尔茨海默病模型小鼠脑组织，发现BRINP1与β-淀粉样蛋白沉积区域共定位，提示其可能参与神经退行性病变的分子机制。
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如需具体文献，建议在PubMed或Google Scholar中检索 **"BRINP1 antibody"** 或 **"anti-BRINP1"** 获取最新研究。
The BRINP1 (BMP/RA-Inducible Neural-Specific Protein 1) antibody is a tool used to detect and study the BRINP1 protein, a member of the BRINP family implicated in neural development and disease. BRINP1. also known as FAM5C, is a neural-specific protein initially identified as a downstream target of bone morphogenetic protein (BMP) and retinoic acid (RA) signaling pathways. It is highly expressed in the brain, particularly in neurons, and plays roles in regulating cell cycle exit, neuronal differentiation, and synaptic plasticity. Structurally, BRINP1 contains conserved domains like the KY domain, which may mediate protein-protein interactions.
Research using BRINP1 antibodies has linked this protein to neurodevelopmental and psychiatric disorders. Altered BRINP1 expression is observed in schizophrenia, autism spectrum disorders, and Alzheimer's disease, suggesting its involvement in synaptic dysfunction or neurodegeneration. Additionally, BRINP1 has been studied in cancer contexts, where its dysregulation correlates with tumor progression in gliomas and other malignancies.
The BRINP1 antibody enables applications such as Western blotting, immunohistochemistry, and immunofluorescence to map its expression patterns, quantify protein levels, or investigate interactions in cellular models. Validated antibodies typically target specific epitopes, ensuring specificity for human, mouse, or rat BRINP1 homologs. Ongoing studies aim to clarify its molecular mechanisms, including potential roles in apoptosis inhibition or extracellular matrix remodeling, highlighting its therapeutic and diagnostic potential.
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