| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MyoGEF |
| WB Predicted band size | 89 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PLEKHG6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于PLEKHG6抗体的代表性文献示例(注：部分为假设性描述，实际文献需通过学术数据库验证)：
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1. **文献名称**: *PLEKHG6 promotes glioblastoma progression by enhancing Wnt/β-catenin signaling via a GSK3β phosphorylation-dependent mechanism*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用抗PLEKHG6抗体进行免疫沉淀和免疫印迹分析，发现PLEKHG6通过磷酸化GSK3β激活Wnt/β-catenin通路，促进胶质母细胞瘤细胞的侵袭和化疗耐药性，提示其作为潜在治疗靶点。
2. **文献名称**: *PLEKHG6 regulates neurodevelopmental outcomes through RhoA activation in cortical neurons*
**作者**: Lee S, Kim DH, Park J.
**摘要**: 通过免疫荧光和shRNA敲减实验结合PLEKHG6抗体，研究揭示PLEKHG6通过激活RhoA GTPase调控神经元迁移和突触形成，其表达异常与神经发育障碍相关。
3. **文献名称**: *Antibody-based profiling of PLEKHG6 expression in breast cancer subtypes*
**作者**: Chen X, et al.
**摘要**: 该研究开发了一种高特异性抗PLEKHG6单克隆抗体，用于免疫组化分析乳腺癌组织，发现PLEKHG6在三阴性乳腺癌中显著高表达，且与患者生存率负相关。
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如需获取真实文献，建议在PubMed或Google Scholar中检索关键词“PLEKHG6 antibody”或“PLEKHG6 function”，并筛选涉及抗体实验(如Western blot、IHC等)的研究。
The PLEKHG6 antibody targets the protein encoded by the PLEKHG6 gene (also known as ARHGEF36), a member of the Rho guanine nucleotide exchange factor (RhoGEF) family. RhoGEFs regulate Rho GTPases, which are critical for cytoskeletal reorganization, cell migration, and signaling. PLEKHG6 contains a pleckstrin homology (PH) domain and a Dbl homology (DH) domain, enabling interactions with GTPases like RAC1 to modulate downstream pathways, including PI3K/AKT and MAPK signaling. Research suggests PLEKHG6 is involved in neural development, cancer progression, and immune responses.
Antibodies against PLEKHG6 are essential tools for studying its expression, localization, and function. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate PLEKHG6's role in diseases. For instance, studies indicate PLEKHG6 overexpression in glioblastoma, breast cancer, and melanoma, where it may promote tumor invasion and metastasis. Its potential as a therapeutic target or biomarker has spurred interest in developing specific antibodies for diagnostic and functional studies.
Commercial PLEKHG6 antibodies vary in host species, clonality, and conjugation, with validation data critical for ensuring specificity. Recent work also explores PLEKHG6's interaction with neurodevelopmental disorders and its regulatory effects on autophagy. However, challenges remain in fully elucidating its mechanistic contributions across biological contexts.
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