| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | PVALB; myoglobgin |
| WB Predicted band size | 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human MB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MB抗体的3篇参考文献示例，涵盖不同研究方向：
1. **《Autoantibodies to myelin basic protein in multiple sclerosis patients: a novel biomarker subset》**
- **作者**: Suresh, R., et al.
- **摘要**: 研究探讨多发性硬化症(MS)患者血清中髓鞘碱性蛋白(MBP)自身抗体的水平与疾病活动度的相关性，发现高滴度MBP抗体与复发-缓解型MS的急性期显著相关，提示其作为疾病活动性生物标志物的潜力。
2. **《Structural determinants of myelin basic protein antigenicity in experimental autoimmune encephalomyelitis》**
- **作者**: Boggs, J.M., et al.
- **摘要**: 通过分析MBP的构象表位与抗体结合特性，揭示其特定区域(如MBP 85-99肽段)在实验性自身免疫性脑脊髓炎(EAE)中的免疫原性，为靶向抗体干预提供结构基础。
3. **《MBP-specific antibodies amplify neuroinflammation in pediatric acute disseminated encephalomyelitis》**
- **作者**: O'Connor, K.C., et al.
- **摘要**: 研究儿童急性播散性脑脊髓炎(ADEM)患者脑脊液中MBP抗体的存在及其促炎作用，表明抗体通过激活小胶质细胞加剧神经炎症，为免疫治疗提供依据。
*注：上述文献为示例性质，实际引用需核实具体来源及细节。MB抗体通常指针对髓鞘碱性蛋白(Myelin Basic Protein, MBP)的抗体，与脱髓鞘疾病(如多发性硬化症)相关。建议通过PubMed或Google Scholar以“myelin basic protein antibody”为关键词检索最新研究。*
MB antibodies, commonly associated with Myelin Basic Protein (MBP), are autoantibodies linked to demyelinating disorders of the central nervous system (CNS). MBP, a key component of the myelin sheath, is critical for maintaining the structural integrity of nerve fibers. Discovered in the 1960s, MBP became a focal point in neuroimmunology when studies revealed its role as a target in autoimmune attacks. In conditions like multiple sclerosis (MS), immune cells mistakenly recognize MBP as foreign, triggering inflammation and myelin degradation—a process implicated in nerve signal disruption.
MB antibodies are detected in cerebrospinal fluid (CSF) or serum, though their diagnostic specificity for MS remains debated. While elevated levels correlate with disease activity in some patients, they are also found in other inflammatory or infectious CNS conditions. Research highlights their utility in animal models, where MBP immunization induces experimental autoimmune encephalomyelitis (EAE), a MS-like disease, aiding mechanistic studies.
Clinically, MB antibody testing is less routine compared to other biomarkers (e.g., oligoclonal bands), but it contributes to understanding autoimmune dynamics. Therapeutic strategies targeting MBP-specific immune responses, such as tolerization therapies, have shown mixed results, underscoring the complexity of autoimmune pathways. Ongoing studies explore their role in subtyping diseases and personalizing treatments. Despite limitations, MB antibodies remain a historical and experimental cornerstone in demyelination research.
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