| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | Bex; NADE; HGR74; NGFRAP1; DXS6984E |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human BEX3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是基于学术文献的模拟示例(请注意，以下信息为示例性质，具体文献需通过数据库查询验证)：
1. **文献名称**：The Role of BEX3 in Neural Stem Cell Differentiation
**作者**：Smith A, et al.
**摘要**：本研究利用BEX3抗体通过免疫印迹和免疫荧光技术，证实BEX3蛋白在小鼠神经干细胞分化过程中表达上调，并调控Notch信号通路，影响神经元与胶质细胞命运决定。
2. **文献名称**：BEX3 Expression Correlates with Glioma Progression
**作者**：Zhang L, et al.
**摘要**：通过BEX3抗体对胶质瘤组织进行免疫组化分析，发现BEX3高表达与患者不良预后相关，体外实验表明沉默BEX3可抑制肿瘤细胞增殖和侵袭能力。
3. **文献名称**：BEX3 Interaction with p75NTR in Alzheimer’s Disease Models
**作者**：Chen R, et al.
**摘要**：研究使用BEX3抗体进行共免疫沉淀实验，揭示BEX3与神经营养因子受体p75NTR的相互作用，可能参与β-淀粉样蛋白诱导的神经元凋亡过程，为阿尔茨海默病机制提供新视角。
4. **文献名称**：BEX3 Modulates ERα Signaling in Breast Cancer
**作者**：Wang Y, et al.
**摘要**：通过BEX3抗体检测乳腺癌细胞系，发现BEX3通过稳定雌激素受体α(ERα)增强下游基因转录，促进激素依赖性肿瘤生长，提示其作为治疗靶点的潜力。
**注意**：以上内容为模拟生成的示例，实际文献需通过PubMed、Google Scholar等平台以“BEX3 antibody”、“BEX3 protein function”等关键词检索获取。
The Brain Expressed X-linked 3 (BEX3) protein, also known as CDX3 or NAG14. is a member of the BEX/GRB7 family involved in neuronal development, apoptosis, and cell cycle regulation. Primarily expressed in the brain, BEX3 interacts with neurotrophic receptors (e.g., TrkA) and signaling pathways like NF-κB, modulating neural differentiation and survival. It acts as an adaptor protein, linking receptor tyrosine kinases to downstream effectors, and influences transcriptional activity by associating with chromatin modifiers. Dysregulation of BEX3 is implicated in neurological disorders and cancers. In neuroblastoma and gliomas, BEX3 exhibits dual roles, acting as a tumor suppressor by promoting apoptosis or as an oncogene by enhancing proliferation, depending on cellular context. Reduced BEX3 expression correlates with poor prognosis in some cancers.
BEX3 antibodies are essential tools for studying its expression patterns, subcellular localization, and interactions. They enable detection in tissues or cell lines via Western blot, immunohistochemistry, and immunofluorescence. Research using BEX3 antibodies has highlighted its potential as a biomarker for neurodevelopmental disorders (e.g., autism) and neurodegenerative diseases like Alzheimer’s. However, functional mechanisms remain partially unresolved, particularly its context-dependent roles in cancer. Commercial BEX3 antibodies vary in specificity, requiring careful validation for experimental accuracy. Ongoing studies aim to clarify its therapeutic potential in targeting BEX3-associated pathways.
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