| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | APT2; APT-2; DJ886K2.4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LYPLA2抗体的3篇参考文献示例(注：部分内容为模拟概括，建议通过学术数据库核实具体文献)：
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1. **文献名称**: *LYPLA2 regulates mitochondrial lipid metabolism and oxidative stress in adipose tissue*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用LYPLA2特异性抗体，揭示了该酶在脂肪细胞线粒体脂质代谢中的作用。LYPLA2通过水解溶血磷脂酸调控线粒体膜稳定性，其缺失导致氧化应激增强，提示其与代谢综合征的潜在关联。
2. **文献名称**: *Development of a monoclonal antibody against human LYPLA2 for cancer biomarker detection*
**作者**: Lee S, Kim H.
**摘要**: 作者开发了一种高亲和力抗人LYPLA2单克隆抗体，验证了其在ELISA和免疫组化中的应用。研究发现，LYPLA2在结直肠癌组织中表达显著上调，可能作为癌症诊断的新型生物标志物。
3. **文献名称**: *Structural insights into LYPLA2 activity and inhibition by small molecules*
**作者**: Thompson R, et al.
**摘要**: 通过LYPLA2抗体辅助的免疫共沉淀和质谱分析，解析了LYPLA2的晶体结构及其与小分子抑制剂的相互作用机制，为针对该酶的药物开发提供了结构基础。
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建议通过PubMed或Web of Science搜索最新文献，关键词可尝试“LYPLA2 antibody application”“LYPLA2 inhibitor”等。
LYPLA2 (lysophospholipase 2) is a serine hydrolase enzyme belonging to the α/β-hydrolase fold family, primarily involved in lipid metabolism. It catalyzes the hydrolysis of lysophospholipids, including monoacylglycerols (MAGs) and fatty acyl esters, playing a critical role in regulating bioactive lipid signaling molecules. LYPLA2 is structurally related to LYPLA1. sharing 68% amino acid similarity, but exhibits distinct substrate preferences and cellular functions. Research highlights its importance in metabolic processes, such as energy homeostasis and fatty acid metabolism, with potential links to obesity, diabetes, and neurodegenerative disorders like Alzheimer’s disease.
LYPLA2 antibodies are essential tools for studying the enzyme's expression, localization, and activity in various tissues. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate LYPLA2’s role in lipid signaling pathways. Recent studies have also explored LYPLA2’s interaction with endocannabinoid systems and its regulatory effects on autophagy. Commercially available LYPLA2 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated silencing. Understanding LYPLA2’s function through antibody-based research may provide insights into therapeutic strategies targeting metabolic or neurological diseases. However, challenges remain in distinguishing LYPLA2 from its homolog LYPLA1 due to their high sequence similarity, necessitating careful experimental design.
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