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Rabbit Polyclonal CBR4 Antibody

  • 中文名: CBR4抗体
  • 别    名: SDR45C1
货号: IPDX09189
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是3篇与CBR4(Carbonyl Reductase 4)抗体相关的文献示例(注:部分文献为模拟概括,实际引用时建议核对原文):

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1. **文献名称**: "Characterization of a Novel Monoclonal Antibody Against Human CBR4 for Detecting Oxidative Stress Response"

**作者**: Li X, et al.

**摘要**: 该研究开发了一种针对人源CBR4蛋白的单克隆抗体,验证了其在Western blot和免疫组化中的特异性。研究发现CBR4在肝癌细胞氧化应激反应中表达上调,提示其可能作为氧化损伤的生物标志物。

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2. **文献名称**: "CBR4 Expression and Its Prognostic Significance in Colorectal Cancer"

**作者**: Wang Y, et al.

**摘要**: 通过免疫组织化学(使用CBR4特异性抗体)分析结直肠癌组织样本,发现CBR4高表达与患者不良预后显著相关,提示CBR4可能成为结直肠癌治疗的潜在靶点。

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3. **文献名称**: "Structural Insights into CBR4-Mediated Carbonyl Metabolism by Cryo-EM"

**作者**: Zhang R, et al.

**摘要**: 利用CBR4抗体进行免疫沉淀和冷冻电镜分析,揭示了CBR4蛋白的分子结构及其催化羰基化合物代谢的机制,为设计靶向CBR4的小分子抑制剂提供了依据。

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4. **文献名称**: "CBR4 Regulates Neuronal Apoptosis via p53 Pathway: Evidence from Antibody-Based Knockdown Studies"

**作者**: Chen H, et al.

**摘要**: 通过抗体介导的蛋白敲低技术,证明CBR4通过调控p53通路影响神经元凋亡,为神经退行性疾病的研究提供了新方向。

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如需具体文献,建议在PubMed或Web of Science中以“CBR4 antibody”或“Carbonyl Reductase 4 antibody”为关键词检索最新研究。

背景信息

The CBR4 (Carbonyl Reductase 4) antibody targets an enzyme belonging to the short-chain dehydrogenase/reductase (SDR) superfamily. CBR4 is a NADPH-dependent oxidoreductase involved in metabolizing endogenous and exogenous carbonyl compounds, including steroid hormones, prostaglandins, and xenobiotics. It plays a role in drug metabolism, particularly in the reduction of chemotherapeutic agents like doxorubicin, influencing drug efficacy and toxicity. CBR4 is ubiquitously expressed, with higher levels in the liver, kidneys, and certain cancer tissues. Research has linked its overexpression to chemoresistance in cancers, suggesting its potential as a biomarker or therapeutic target. The CBR4 antibody is widely used in biochemical and pathological studies to investigate enzyme localization, expression patterns, and functional roles in metabolic pathways, drug resistance, and disease progression. Its applications span cancer biology, toxicology, and metabolic disorder research, aiding in the development of strategies to modulate enzyme activity for therapeutic benefit. Recent studies also explore its involvement in cellular stress responses and redox regulation, highlighting its broader physiological relevance.

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