| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 76 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human LRRC45 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LRRC45抗体的3篇示例文献(注：因实际文献可能有限，以下内容为模拟示例，仅供参考)：
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1. **文献名称**：*LRRC45 is a ciliary protein involved in dynein assembly*
**作者**：Smith A, et al.
**摘要**：本研究利用特异性LRRC45抗体，发现LRRC45在纤毛发生中与动力蛋白复合体相互作用，并通过免疫沉淀验证其调控纤毛运动的分子机制。
2. **文献名称**：*Development and validation of a monoclonal antibody against human LRRC45*
**作者**：Chen L, et al.
**摘要**：报道了一种针对人源LRRC43蛋白的单克隆抗体的开发与验证，通过Western blot和免疫荧光证实其在多种细胞系中的特异性识别能力。
3. **文献名称**：*LRRC45 expression correlates with prognosis in glioblastoma*
**作者**：Wang Y, et al.
**摘要**：利用LRRC45抗体进行免疫组化分析，发现LRRC45在胶质母细胞瘤中高表达，且与患者生存率显著相关，提示其作为潜在生物标志物的可能性。
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**备注**：实际研究中关于LRRC45抗体的文献可能较少，建议通过PubMed或Google Scholar以“LRRC45 antibody”为关键词检索最新文献，或关注相关功能研究(如纤毛发生、癌症等领域)中抗体的应用描述。
**Background of LRRC45 Antibody**
LRRC45 (Leucine-Rich Repeat-Containing Protein 45) is a member of the leucine-rich repeat (LRR) protein family, characterized by repetitive structural motifs involved in protein-protein interactions, signaling pathways, and cellular organization. While the precise biological function of LRRC45 remains under investigation, studies suggest its potential role in ciliogenesis, microtubule dynamics, and cellular trafficking, with implications in cilia-related disorders, cancer, and neurological conditions.
LRRC45 antibodies are immunological tools designed to detect and study the expression, localization, and interactions of the LRRC45 protein in various experimental models. These antibodies are commonly used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate LRRC45's tissue-specific distribution, subcellular localization (e.g., association with centrosomes or ciliary structures), and dysregulation in disease contexts.
Commercial LRRC45 antibodies are typically generated using immunogenic peptide sequences derived from conserved regions of the human or murine LRRC45 protein. They are available as monoclonal or polyclonal formats, often validated in specific applications. However, due to limited characterization of LRRC45 and potential cross-reactivity with other LRR family proteins, rigorous validation (e.g., knockout controls) is essential for ensuring antibody specificity. Current research utilizing LRRC45 antibodies aims to clarify its functional mechanisms, interactome, and therapeutic relevance in diseases linked to ciliary dysfunction or cellular misregulation.
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