| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human LRRC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是基于LRRC2相关研究的模拟参考文献示例，供参考。请注意，这些文献为示例性质，实际文献请通过学术数据库(如PubMed、Google Scholar)检索最新信息：
---
1. **标题**: *LRRC2 functions as a tumor suppressor in non-small cell lung cancer via modulating TGF-β signaling*
**作者**: Chen X, Wang Y, Li Z et al.
**摘要**: 本研究通过免疫组化(使用兔源抗人LRRC2多克隆抗体)发现，LRRC2在肺癌组织中表达显著下调，且低表达与患者不良预后相关。实验验证LRRC2通过抑制TGF-β/Smad通路抑制肿瘤转移。
2. **标题**: *Development and characterization of a monoclonal antibody specific to human LRRC2 for cardiac development studies*
**作者**: Tanaka K, Sato R, Yamamoto H.
**摘要**: 文章报道了一种新型小鼠抗人LRRC2单克隆抗体的开发，经Western blot和免疫荧光验证其特异性。该抗体被用于小鼠胚胎心脏组织分析，揭示LRRC2在心室间隔发育中的关键作用。
3. **标题**: *LRRC2 interacts with Wnt/β-catenin pathway components in gastric cancer progression*
**作者**: Liu H, Zhang Q, Wei F et al.
**摘要**: 通过免疫共沉淀(使用商业抗LRRC2抗体，货号AB123)和质谱分析，研究发现LRRC2与β-catenin存在直接相互作用，抑制Wnt信号通路活性，从而延缓胃癌细胞增殖。
---
**建议**：
如需真实文献，可访问PubMed(https://pubmed.ncbi.nlm.nih.gov/)并检索关键词“LRRC2 antibody”或“LRRC2 function”，筛选涉及抗体开发或应用的实验性论文。
The LRRC2 (Leucine-Rich Repeat-Containing 2) protein belongs to the leucine-rich repeat (LRR) superfamily, characterized by repeating units of 20-30 amino acids rich in leucine residues. These proteins are involved in diverse cellular processes, including protein-protein interactions, signal transduction, and immune regulation. LRRC2. though less studied than other LRR family members, is hypothesized to play roles in cell adhesion, neuronal development, or receptor signaling due to structural similarities with related LRR proteins. Its expression has been detected in multiple tissues, with studies suggesting potential links to cancer progression and neurological disorders.
LRRC2 antibodies are immunological tools designed to detect and study the expression, localization, and function of the LRRC2 protein. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate LRRC2's tissue distribution, subcellular localization, and dysregulation in disease models. Commercial LRRC2 antibodies are typically raised in hosts like rabbits or mice using peptide antigens derived from conserved regions of the human LRRC2 sequence. Validation often includes knockout cell line controls to confirm specificity. Researchers utilize these antibodies to explore LRRC2's involvement in pathways like Wnt/β-catenin or NF-κB, particularly in contexts such as tumor metastasis or neural circuit formation. However, variability in antibody performance across applications underscores the need for rigorous validation in experimental systems.
×
