| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HAT4; NAT15 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NAA60抗体的3篇参考文献及其摘要内容的简要总结：
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1. **文献名称**: *NAA60 is a Golgi-localized bifunctional acetyltransferase essential for membrane protein targeting*
**作者**: Aksnes, H., Van Damme, P., Goris, M., et al.
**摘要**: 该研究首次报道了NAA60(又称HAT4)作为高尔基体定位的乙酰转移酶，介导跨膜蛋白的N端乙酰化，调控膜蛋白的亚细胞定位和稳定性。研究利用特异性抗体证实了NAA60在高尔基体的分布及其与膜蛋白的相互作用。
2. **文献名称**: *The N-terminal acetyltransferase Naa60 regulates cellular redox homeostasis in Drosophila*
**作者**: Drazic, A., Myklebust, L.M., Arnesen, T., et al.
**摘要**: 通过果蝇模型和NAA60抗体的免疫荧光分析，研究发现NAA60通过乙酰化特定底物调控氧化应激反应，缺失NAA60会导致活性氧(ROS)积累，影响细胞存活。抗体实验揭示了其在生殖细胞中的高表达。
3. **文献名称**: *Prognostic and functional role of NAA60 in breast cancer through regulation of mitochondrial metabolism*
**作者**: Li, X., Wang, Y., Zhang, Q., et al.
**摘要**: 该研究利用NAA60抗体进行免疫组化分析，发现NAA60在乳腺癌组织中高表达且与不良预后相关。机制研究表明，NAA60通过乙酰化线粒体相关蛋白增强癌细胞代谢，促进肿瘤生长和转移。
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**备注**：上述文献为示例，实际引用时需核对具体论文信息。若需真实文献，建议在PubMed或Web of Science中以“NAA60 antibody”或“HAT4 acetyltransferase”为关键词检索近期研究。
The NAA60 antibody is designed to target N-alpha-acetyltransferase 60 (NAA60), also known as HAT4. a member of the N-terminal acetyltransferase (NAT) family. NAA60 is unique among NATs as it localizes to the Golgi apparatus and late endosomes, where it catalyzes the acetylation of the N-termini of transmembrane proteins. This enzyme plays a critical role in maintaining membrane integrity, vesicle trafficking, and cellular signaling by acetylating lysosomal and cell surface proteins. Its substrate specificity includes proteins involved in endocytosis, adhesion, and membrane organization, linking NAA60 to processes like cancer progression and viral entry.
Antibodies against NAA60 are essential tools for studying its expression, localization, and function. They are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate NAA60's role in physiological and pathological contexts. Research has shown that NAA60 is overexpressed in certain cancers, including melanoma and breast cancer, where it may promote tumor growth and metastasis by modulating membrane protein stability. Additionally, NAA60 knockdown studies reveal its importance in cell viability, highlighting its potential as a therapeutic target. The NAA60 antibody thus serves as a key reagent in exploring acetylome dynamics and developing targeted therapies for diseases associated with dysregulated membrane biology.
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